Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 2/20 | 0.37 |
| ▸ | GHSR | Q92847 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274994 | 0.87 | GHSR (0.51) | CTSKCTSSCTSCGHSR | |
| SCHEMBL1401241 | 0.86 | CYP2C19 (0.50) | CTSKCTSSCYP2C19RIPK1CTSC | |
| SCHEMBL6317809 | 0.83 | CTSK (0.47) | CTSKCTSSCYP2C19RIPK1CTSC | |
| SCHEMBL3266943 | 0.82 | CTSK (0.47) | CTSKCTSSCYP2C19RIPK1CTSC | |
| SCHEMBL3267790 | 0.82 | CTSS (0.38) | CTSKCTSSCYP2C19RIPK1CTSC | |
| SCHEMBL3268338 | 0.80 | REN (0.44) | CTSKCTSSMMP13 | |
| SCHEMBL6318786 | 0.79 | CTSK (0.45) | CTSKCTSSCYP2C19RIPK1CTSC | |
| SCHEMBL6319015 | 0.76 | CTSK (0.45) | CTSKCTSSCYP2C19RIPK1CTSC | |
| SCHEMBL6316639 | 0.76 | CTSK (0.41) | CTSKCTSSCYP2C19RIPK1CTSC | |
| SCHEMBL8190649 | 0.75 | GHSR (0.51) | CTSKCTSSCTSCGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506969-B1 | Compounds with growth hormone releasing properties | HELSINN THERAPEUTICS US INC (US) | 2010-06-09 | — | — | EP | disclosed |
| EP-1506969-A1 | Compounds with growth hormone releasing properties | NOVO NORDISK A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| EP-1047709-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2004-11-03 | — | — | EP | disclosed |
| WO-1999036431-A9 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2000-07-27 | — | — | WO | disclosed |
| US-6083908-A | TREATING MEDICAL DISORDERS RESULTING FROM DEFICIENCY IN GROWTH HORMONE | NOVO NORDISK A/S (DK) | 2000-07-04 | — | — | US | disclosed |