Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSC | P53634 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | BMP1 | P13497 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6317809 | 0.89 | CTSK (0.47) | CTSKCTSSCTSCMMP13CYP2C19 | |
| SCHEMBL1401241 | 0.85 | CYP2C19 (0.50) | CTSKCTSSCTSCMMP13CYP2C19 | |
| SCHEMBL3266957 | 0.85 | GHSR (0.49) | CTSKCTSSCTSCBMP1 | |
| SCHEMBL3266809 | 0.82 | CTSK (0.43) | CTSKCTSSCTSCMMP13CYP2C19 | |
| SCHEMBL3268116 | 0.81 | REN (0.49) | CTSKCTSSMMP13AAK1 | |
| SCHEMBL3268094 | 0.81 | REN (0.49) | CTSKCTSSMMP13AAK1 | |
| SCHEMBL3267790 | 0.78 | CTSS (0.38) | CTSKCTSSCTSCCYP2C19RAB9A | |
| SCHEMBL6318786 | 0.78 | CTSK (0.45) | CTSKCTSSCTSCCYP2C19RAB9A | |
| SCHEMBL6319015 | 0.78 | CTSK (0.45) | CTSKCTSSCTSCCYP2C19RAB9A | |
| SCHEMBL6316639 | 0.73 | CTSK (0.41) | CTSKCTSSCTSCMMP13CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506969-B1 | Compounds with growth hormone releasing properties | HELSINN THERAPEUTICS US INC (US) | 2010-06-09 | — | — | EP | disclosed |
| EP-1506969-A1 | Compounds with growth hormone releasing properties | NOVO NORDISK A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| EP-1047709-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2004-11-03 | — | — | EP | disclosed |
| EP-1047709-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036431-A9 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2000-07-27 | — | — | WO | disclosed |
| US-6083908-A | TREATING MEDICAL DISORDERS RESULTING FROM DEFICIENCY IN GROWTH HORMONE | NOVO NORDISK A/S (DK) | 2000-07-04 | — | — | US | disclosed |
| WO-1999036431-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1999-07-22 | — | — | WO | disclosed |