SCHEMBL32669822

SCHEMBL32669822

CN(C)C(=O)Cc1cccc(OCCN(C)C(=O)/C(C#N)=C(\O)c2cc(Cl)c(O)c(Cl)c2)c1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LTB4R Q15722 3/20 0.41
LTB4R2 Q9NPC1 3/20 0.41
KDM4E B2RXH2 3/20 0.38
ATM Q13315 1/20 0.37
CYP2D6 P10635 6/20 0.36
KCNH2 Q12809 2/20 0.35
F10 P00742 1/20 0.35
ALOX5 P09917 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
ESR1 P03372 1/20 0.34
SIGMAR1 Q99720 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32670068 0.87 KDM4E (0.37) LTB4RLTB4R2KDM4EATMALDH1A1
SCHEMBL32669627 0.82 FTO (0.43) LTB4RLTB4R2KDM4EALDH1A1
SCHEMBL32670048 0.82 SMN1; SMN2 (0.41) KDM4EALDH1A1
SCHEMBL32669930 0.81 RAB9A (0.38) KDM4EATMALDH1A1LMNAESR1
SCHEMBL32669759 0.79 PORCN (0.36) KDM4EESR1
SCHEMBL32669969 0.78 FTO (0.50) KDM4EALDH1A1LMNA
SCHEMBL32669571 0.77 SLC22A12 (0.36) KDM4EESR1
SCHEMBL32669598 0.74 COMT (0.32) KDM4EALDH1A1
SCHEMBL32669726 0.72 SLC22A12 (0.39) LTB4RLTB4R2SIGMAR1
SCHEMBL32669541 0.71 TTR (0.44) ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 LTB4R 2428/4885LTB4R2 3555/4885KDM4E 374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.