Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27921658 | 0.88 | LMNA (0.59) | TDP1L3MBTL1ALDH1A1ESR2PTPN1 | |
| SCHEMBL10737141 | 0.87 | CYP4F2 (0.52) | TDP1L3MBTL1CYP4F2CYP4A11CYSLTR2 | |
| SCHEMBL9469608 | 0.86 | NPC1 (0.49) | TDP1L3MBTL1CYP4F2CYP4A11CYSLTR2 | |
| SCHEMBL29213722 | 0.86 | TDP1 (0.64) | TDP1USP2ALDH1A1LMNA | |
| SCHEMBL3268399 | 0.84 | JAK2 (0.53) | TDP1L3MBTL1CYP4F2CYP4A11CYSLTR2 | |
| SCHEMBL27838097 | 0.84 | TBXAS1 (0.58) | TDP1L3MBTL1CYP4F2CYP4A11DHFR | |
| SCHEMBL8158473 | 0.84 | HTR1A (0.54) | TDP1L3MBTL1LTA4HALDH1A1LMNA | |
| SCHEMBL8955675 | 0.84 | TDP1 (0.51) | TDP1L3MBTL1CYSLTR2CYSLTR1DHFR | |
| SCHEMBL8158041 | 0.84 | PPARG (0.58) | TDP1L3MBTL1CYP4F2CYP4A11CYSLTR2 | |
| SCHEMBL2987183 | 0.83 | CYP1A2 (0.58) | TDP1L3MBTL1CYP4F2CYP4A11CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3546452-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MMV Medicines for Malaria Venture (CH) | 2019-10-02 | — | — | EP | disclosed |
| EP-2194985-B1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2019-02-20 | — | — | EP | disclosed |
| US-8530491-B2 | Antimalarial compounds with flexible side-chains | MEDICINES FOR MALARIA VENTURE (MMV) (CH) | 2013-09-10 | — | — | US | disclosed |
| EP-2194985-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | Medicines for Malaria Venture (CH) | 2010-06-16 | — | — | EP | disclosed |
| US-20090099220-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MEDICINES FOR MALARIA VENTURE | 2009-04-16 | — | — | US | disclosed |
| WO-2009048957-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MEDICINES FOR MALARIA VENTURE (CH) | 2009-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099220-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | DHFR, FPGS, DHODH | TDP1 2135/4885L3MBTL1 420/4885CYP4F2 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.