Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27856261 | 0.96 | MEN1 (0.44) | ALDH1A1RORCDHODHMEN1KMT2A | |
| SCHEMBL690572 | 0.91 | RORC (0.40) | ALDH1A1RORCDHODHMEN1KMT2A | |
| SCHEMBL27856266 | 0.88 | KMT2A (0.46) | ALDH1A1RORCDHODHMEN1KMT2A | |
| SCHEMBL3233896 | 0.88 | RORC (0.40) | ALDH1A1RORCDHODHMEN1KMT2A | |
| SCHEMBL3267550 | 0.86 | MTNR1B (0.43) | ALDH1A1RORCDHODHMEN1KMT2A | |
| SCHEMBL3267160 | 0.86 | FAAH (0.38) | ALDH1A1RORCDHODHMEN1KMT2A | |
| SCHEMBL690228 | 0.84 | EPHX2 (0.42) | ALDH1A1RORCDHODHMEN1KMT2A | |
| SCHEMBL3228834 | 0.84 | EPHX2 (0.42) | ALDH1A1RORCDHODHMEN1KMT2A | |
| SCHEMBL689275 | 0.84 | EPHX2 (0.42) | ALDH1A1RORCDHODHMEN1KMT2A | |
| SCHEMBL27856260 | 0.83 | HTR1A (0.42) | ALDH1A1MEN1KMT2AALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102186818-B | 7-(piperazine-1-ymethyl)-1h-indole-2-carboxylic acid (phenyl)-amide derivatives and allied compounds as p38 map kinase inhibitors for the treatment of respiratory diseases | BOEHRINGER INGELHEIM INT | 2013-10-02 | — | — | CN | disclosed |
| CN-102186818-A | 7-(piperazine-1-ymethyl)-1h-indole-2-carboxylic acid (phenyl)-amide derivatives and allied compounds as p38 map kinase inhibitors for the treatment of respiratory diseases | BOEHRINGER INGELHEIM INT | 2011-09-14 | — | — | CN | disclosed |
| WO-2010026096-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |