SCHEMBL3267660

SCHEMBL3267660

C=CC(=O)Nc1ccc(I)cc1C(=O)OC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPRC P08575 1/20 0.44
PTPN2 P17706 1/20 0.44
PTPN1 P18031 1/20 0.44
PTPRA P18433 1/20 0.44
PTPRB P23467 1/20 0.44
PTPRE P23469 1/20 0.44
PTPN6 P29350 1/20 0.44
HPGD P15428 4/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TGM2 P21980 2/20 0.42
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA7 P43166 2/20 0.41
CA9 Q16790 2/20 0.41
CA14 Q9ULX7 2/20 0.41
PDK2 Q15119 1/20 0.41
PDK4 Q16654 1/20 0.41
KDM4E B2RXH2 6/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3265331 0.85 CA12 (0.56) HPGDHTTSMN1; SMN2TGM2CA12
SCHEMBL3262750 0.83 PTPN1 (0.64) PTPRCPTPN2PTPN1PTPRAPTPRB
SCHEMBL21431006 0.82 TGM2 (0.56) HPGDHTTSMN1; SMN2TGM2KDM4E
SCHEMBL4736951 0.82 ABL1 (0.49) HPGDHTTSMN1; SMN2TGM2KDM4E
SCHEMBL4736645 0.78 HPGD (0.68) HPGDHTTSMN1; SMN2KDM4EATM
SCHEMBL6223409 0.78 KDM4E (0.58) PTPRCPTPN2PTPN1PTPRAPTPRB
SCHEMBL5735678 0.78 PTPRC (0.44) PTPRCPTPN2PTPN1PTPRAPTPRB
SCHEMBL24893527 0.78 HTT (0.45) PTPRCPTPN2PTPN1PTPRAPTPRB
SCHEMBL22650326 0.78 HTT (0.50) PTPRCPTPN2PTPN1PTPRAPTPRB
SCHEMBL6046819 0.77 KMT2A (0.53) PTPRCPTPN2PTPN1PTPRAPTPRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110294853-A1 Bis Aromatic Compounds for Use in the Treatment of Inflammation BIOLIPOX AB (SE) 2011-12-01 US disclosed
WO-2010029300-A1 BIS AROMATIC COMPOUNDS FOR USE IN THE TREATMENT OF INFLAMMATION BIOLIPOX AB (SE) 2010-03-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110294853-A1 Bis Aromatic Compounds for Use in the Treatment of Inflammation LTC4S, LTB4R2, LTB4R PTPRC 3167/4885PTPN2 3644/4885PTPN1 3735/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.