Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.64 |
| ▸ | SKP1 | P63208 | 2/20 | 0.64 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.64 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | WNT3A | P56704 | 2/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.49 |
| ▸ | ITGAL | P20701 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29157436 | 0.88 | LRRK2 (0.54) | CKS1BSKP1SKP2GPR119LRRK2 | |
| SCHEMBL1705150 | 0.87 | CKS1B (0.55) | CKS1BSKP1SKP2GPR119KIT | |
| SCHEMBL15228419 | 0.84 | GPR119 (0.56) | CKS1BSKP1SKP2GPR119LRRK2 | |
| SCHEMBL20938623 | 0.83 | PIK3CA (0.56) | CKS1BSKP1SKP2GPR119KIT | |
| SCHEMBL113805 | 0.83 | GPR119 (0.55) | CKS1BSKP1SKP2GPR119LRRK2 | |
| SCHEMBL3267870 | 0.82 | CKS1B (0.65) | CKS1BSKP1SKP2GPR119KIT | |
| SCHEMBL3273530 | 0.82 | CKS1B (0.62) | CKS1BSKP1SKP2GPR119KIT | |
| SCHEMBL1459701 | 0.82 | GPR119 (0.79) | CKS1BSKP1SKP2GPR119 | |
| SCHEMBL30516861 | 0.82 | GPR119 (0.79) | CKS1BSKP1SKP2GPR119 | |
| SCHEMBL3442387 | 0.82 | ALDH1A1 (0.56) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812025-B2 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-10-12 | — | — | US | disclosed |
| US-20090048263-A1 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-02-19 | — | — | US | disclosed |
| EP-1923388-A1 | BRAIN/NEURONAL CELL-PROTECTING AGENT, AND THERAPEUTIC AGENT FOR SLEEP DISORDER | Takeda Pharmaceutical Company Limited (JP) | 2008-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048263-A1 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | HCRTR1, HCRTR2, MTNR1A | CKS1B 2582/4885SKP1 734/4885SKP2 1308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.