SCHEMBL32688073

SCHEMBL32688073

COC(=O)CSc1nc(-c2ccccc2)nc(=O)[nH]1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.57
▸ PRNP P04156 3/20 0.57
▸ L3MBTL1 Q9Y468 2/20 0.57
▸ KMT2A Q03164 1/20 0.51
▸ HPGD P15428 4/20 0.48
▸ ALDH1A1 P00352 2/20 0.48
▸ RXFP1 Q9HBX9 2/20 0.48
▸ ALOX15 P16050 1/20 0.48
▸ MAPK1 P28482 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ MAPK14 Q16539 1/20 0.47
▸ PTGES O14684 1/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ LMNA P02545 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ POLB P06746 2/20 0.45
▸ GAA P10253 2/20 0.44
▸ CYP1A2 P05177 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688395 0.85 KDM4E (0.62) KDM4EKMT2AHPGDALDH1A1HSD17B10
SCHEMBL32688027 0.77 MEN1 (0.66) KMT2ASMN1; SMN2LMNAMAPTPOLB
SCHEMBL32688002 0.72 ACMSD (0.70) KMT2ASMN1; SMN2POLB
SCHEMBL19342086 0.68 KMT2A (0.81) L3MBTL1KMT2AHPGDALDH1A1MAPK1
SCHEMBL9399130 0.68 HSD17B10 (0.52) KDM4EPRNPL3MBTL1KMT2AHPGD
SCHEMBL28677334 0.67 MAPT (0.53) KDM4EL3MBTL1KMT2AHPGDALDH1A1
SCHEMBL6764561 0.67 FFAR1 (0.61) KDM4EPRNPL3MBTL1KMT2AHPGD
SCHEMBL4360005 0.67 TSHR (0.60) L3MBTL1KMT2AALDH1A1HSD17B10SMN1; SMN2
SCHEMBL28672624 0.66 ADORA3 (0.57) KDM4EL3MBTL1HPGDALDH1A1RXFP1
SCHEMBL9257666 0.66 SMN1; SMN2 (0.40) KDM4EPRNPL3MBTL1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK KDM4E 3207/4885PRNP 3448/4885L3MBTL1 1904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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