SCHEMBL32688235

SCHEMBL32688235

N#Cc1c(SCc2nnn[nH]2)[nH]c(=O)c(CO)c1-c1ccc(Cl)cc1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 10/20 0.45
▸ ACMSD Q8TDX5 1/20 0.38
▸ IDO1 P14902 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ LDHA P00338 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ CXCR2 P25025 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ RXFP1 Q9HBX9 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688269 0.89 HSD11B1 (0.45) HSD11B1ACMSDIDO1MEN1POLB
SCHEMBL32688263 0.86 ACMSD (0.42) HSD11B1ACMSDIDO1MEN1POLB
SCHEMBL32688362 0.85 HSD11B1 (0.39) HSD11B1ACMSDIDO1MEN1POLB
SCHEMBL32688250 0.84 HSD11B1 (0.41) HSD11B1ACMSDIDO1MEN1POLB
SCHEMBL32688422 0.83 MAPT (0.38) HSD11B1ACMSDIDO1MEN1POLB
SCHEMBL32688110 0.83 MAPT (0.38) HSD11B1ACMSDMEN1POLBKMT2A
SCHEMBL32688136 0.82 HSD11B1 (0.41) HSD11B1ACMSDIDO1MEN1POLB
SCHEMBL32688166 0.81 HSD11B1 (0.41) HSD11B1IDO1MEN1KMT2A
SCHEMBL32688201 0.81 HSD11B1 (0.36) HSD11B1IDO1CXCR2
SCHEMBL32688008 0.81 MEN1 (0.42) HSD11B1ACMSDIDO1MEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK HSD11B1 61/4885ACMSD 142/4885IDO1 1284/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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