SCHEMBL32688263

SCHEMBL32688263

N#Cc1c(SCc2nnn[nH]2)[nH]c(=O)c(C(=O)O)c1-c1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ACMSD Q8TDX5 1/20 0.42
▸ HSD11B1 P28845 2/20 0.39
▸ MAPT P10636 1/20 0.38
▸ KMT2A Q03164 3/20 0.37
▸ LMNA P02545 2/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ LDHA P00338 4/20 0.37
▸ IDO1 P14902 1/20 0.35
▸ FNTA P49354 2/20 0.35
▸ FNTB P49356 2/20 0.35
▸ GRIA2 P42262 1/20 0.35
▸ GRIA4 P48058 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ CXCR2 P25025 1/20 0.34
▸ CUL4A Q13619 1/20 0.34
▸ LDHB P07195 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688362 0.91 HSD11B1 (0.39) ACMSDHSD11B1MAPTKMT2ALMNA
SCHEMBL32688422 0.89 MAPT (0.38) ACMSDHSD11B1MAPTKMT2ALMNA
SCHEMBL32688110 0.89 MAPT (0.38) ACMSDHSD11B1MAPTKMT2ALMNA
SCHEMBL32688127 0.88 MAPT (0.45) MAPTKMT2AALDH1A1MEN1POLB
SCHEMBL32688022 0.87 ALDH1A1 (0.52) ACMSDHSD11B1MAPTKMT2ALMNA
SCHEMBL32688269 0.87 HSD11B1 (0.45) ACMSDHSD11B1KMT2ALMNAALDH1A1
SCHEMBL32688001 0.87 CUL4A (0.49) ACMSDHSD11B1MAPTKMT2ALMNA
SCHEMBL32688235 0.86 HSD11B1 (0.45) ACMSDHSD11B1KMT2ALMNAALDH1A1
SCHEMBL32688008 0.81 MEN1 (0.42) ACMSDHSD11B1KMT2AALDH1A1MEN1
SCHEMBL32688250 0.81 HSD11B1 (0.41) ACMSDHSD11B1KMT2ALMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK ACMSD 142/4885HSD11B1 61/4885MAPT 4018/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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