Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Aminothiazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | NOS1 | P29475 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | ACP1 | P24666 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminothiazole SCHEMBL27899272 | 0.85 | — | — | |
| Aminothiazole SCHEMBL7401 | 0.84 | — | — | |
| Aminothiazole SCHEMBL10428703 | 0.84 | — | — | |
| Aminothiazole SCHEMBL4962431 | 0.84 | ALDH1A1 (1.00) | ALDH1A1TSHRNOS1HSD17B10LMNA | |
| Aminothiazole SCHEMBL1241596 | 0.83 | ALDH1A1 (0.75) | ALDH1A1TSHRNOS1HSD17B10ACP1 | |
| Aminothiazole SCHEMBL27943753 | 0.82 | — | — | |
| Aminothiazole SCHEMBL29012817 | 0.82 | — | — | |
| Aminothiazole SCHEMBL28159425 | 0.82 | — | — | |
| Aminothiazole SCHEMBL7473421 | 0.82 | — | — | |
| Aminothiazole SCHEMBL2350289 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-220048138-U | Reaction device for continuously producing 2-bromothiazole | 济南悟通生物科技有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-109942600-A | A kind of preparation method of Yi Dushaban | 内蒙古京东药业有限公司 | 2019-06-28 | — | — | CN | disclosed |
| EP-1241232-B1 | METAL CHELATE DYESTUFF FOR INK JET RECORDING AND WATER-BASE INK JET RECORDING FLUID CONTAINING THE SAME | MITSUBISHI CHEM CORP (JP) | 2010-06-16 | — | — | EP | disclosed |
| US-6755903-B2 | FORMED FROM AN AZO COMPOUND CONTAINING AN N-HETEROARYL RING, E.G., IMIDAZOLE, AND AN OPTIONALLY SUBSTITUTED NAPHTHYL RING AND PREFERABLY A COPPER, NICKEL OR COBALT COMPOUND | MITSUBISHI CHEMICAL CORPORATION (JP) | 2004-06-29 | — | — | US | disclosed |
| US-20030088077-A1 | Formed from an azo compound containing an N-heteroaryl ring, e.g., imidazole, and an optionally substituted naphthyl ring and preferably a copper, nickel or cobalt compound | MITSUBISHI CHEMICAL CORPORATION (JP) | 2003-05-08 | — | — | US | disclosed |
| EP-1241232-A1 | METAL CHELATE DYESTUFF FOR INK JET RECORDING AND WATER-BASE INK JET RECORDING FLUID CONTAINING THE SAME | MITSUBISHI CHEMICAL CORPORATION (JP) | 2002-09-18 | — | — | EP | disclosed |
| EP-0314046-B1 | Method of quantitative analysis of hydrogen peroxide and reagent therefor | DAIICHI PURE CHEMICALS CO LTD (JP) | 1994-06-01 | — | — | EP | disclosed |
| US-4933277-A | Method of quantitative analysis of hydrogen peroxide and reagent therefor | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0314046-A2 | Method of quantitative analysis of hydrogen peroxide and reagent therefor | DAIICHI PURE CHEMICALS CO. LTD. (JP) | 1989-05-03 | — | — | EP | disclosed |
| US-4046752-A | Process for preparing an azo compound from a 2-aminothiazole diazo component | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-09-06 | — | — | US | disclosed |