Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 3/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.37 |
| ▸ | TUBB | P07437 | 4/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3269782 | 0.87 | TYMS (0.41) | TYMSDHFRTUBB4ATUBBTUBA3C | |
| SCHEMBL3270007 | 0.87 | EDNRA (0.44) | DHFRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3269941 | 0.87 | TYMS (0.41) | TYMSTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3269356 | 0.87 | TYMS (0.35) | TYMSDHFRTUBB4ATUBBTUBA3C | |
| SCHEMBL3268800 | 0.84 | RHEB (0.39) | TYMSTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3188930 | 0.82 | TYMS (0.44) | TYMSDHFRTUBB4ATUBBTUBA3C | |
| SCHEMBL3274436 | 0.79 | SIRT1 (0.35) | TYMSDHFRTUBB4ATUBBTUBA3C | |
| SCHEMBL3272659 | 0.76 | EDNRA (0.44) | DHFRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3270312 | 0.73 | TNKS2 (0.39) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4035502 | 0.72 | TUBB4A (0.39) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784409-B1 | SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2010-06-16 | — | — | EP | claimed |