Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.46 |
| ▸ | TSHR | P16473 | 7/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.43 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273039 | 0.88 | CYP2D6 (0.46) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 | |
| SCHEMBL3274284 | 0.84 | CYP2D6 (0.50) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 | |
| SCHEMBL17611736 | 0.79 | USP30 (0.48) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 | |
| SCHEMBL13309551 | 0.77 | HDAC1 (0.56) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 | |
| SCHEMBL19693711 | 0.77 | CYP2D6 (0.50) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 | |
| SCHEMBL8060453 | 0.76 | CYP2D6 (0.72) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 | |
| SCHEMBL24718689 | 0.76 | RIPK1 (0.65) | CYP2D6ALDH1A1TSHRUSP30RIPK1 | |
| SCHEMBL30989078 | 0.76 | OPRD1 (0.53) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 | |
| SCHEMBL12547430 | 0.76 | CYP2D6 (0.53) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 | |
| SCHEMBL4877899 | 0.76 | CYP2D6 (0.65) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071773-B2 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors | NOVARTISAG (CH) | 2011-12-06 | — | — | US | disclosed |
| EP-1885724-B1 | HETEROCYCLIC SPIRO-COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2010-06-23 | — | — | EP | disclosed |
| US-20090111840-A1 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2009-04-30 | — | — | US | disclosed |
| EP-1885724-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | Speedel Experimenta AG (CH) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006128853-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111840-A1 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors | REN, NR3C2, CYP21A2 | CYP2D6 131/4885ALDH1A1 312/4885CYP3A4 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.