Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.43 |
| ▸ | CASP4 | P49662 | 1/20 | 0.43 |
| ▸ | CASP5 | P51878 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CASP9 | P55211 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 5/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470332 | 0.90 | ACE (0.45) | ACESTAT6ELANECMA1CTSL | |
| SCHEMBL3171815 | 0.84 | TSHR (0.49) | PREPALDH1A1TSHRCTSK | |
| SCHEMBL3314939 | 0.82 | HTRA1 (0.39) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL3469548 | 0.82 | ACE (0.46) | ACEPREPCMA1CTSL | |
| SCHEMBL1045607 | 0.81 | CASP1 (0.36) | CASP1CASP3CASP7CASP8CYP3A4 | |
| SCHEMBL3470255 | 0.80 | CTSL (0.45) | ACEPREPFKBP1ACMA1CTSL | |
| SCHEMBL18620597 | 0.79 | ACE (0.60) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL20484674 | 0.79 | ACE (0.60) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL994620 | 0.78 | PREP (0.47) | PREPALDH1A1TSHRCTSK | |
| SCHEMBL3269454 | 0.78 | KLK7 (0.53) | ACEPREPFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278737-B1 | PROCESS AND INTERMEDIATES FOR MAKING SUBSTITUTED ASPARTIC ACID ACETALS | VERTEX PHARMA (US) | 2010-06-30 | — | — | EP | disclosed |
| US-7109357-B2 | Process and intermediates for making substituted aspartic acid acetals | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-09-19 | — | — | US | disclosed |
| US-20030119899-A1 | Process and intermediates for making substituted aspartic acid acetals | VERTEX PHARMACEUTICALS INCORPORATED | 2003-06-26 | — | — | US | disclosed |
| EP-1278737-A2 | PROCESS AND INTERMEDIATES FOR MAKING SUBSTITUTED ASPARTIC ACID ACETALS | Vertex Pharmaceuticals Incorporated (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001081330-A2 | PROCESS AND INTERMEDIATES FOR MAKING SUBSTITUTED ASPARTIC ACID ACETALS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119899-A1 | Process and intermediates for making substituted aspartic acid acetals | CASP1, CASP4, CASP2 | CASP1 1/4885CASP3 5/4885CASP2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.