Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11331981 | 0.84 | PSMB8 (0.51) | ALDH1A1L3MBTL1HTTLMNAMAPT | |
| SCHEMBL6029431 | 0.74 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1HTTLMNAMAPT | |
| SCHEMBL13101265 | 0.73 | CYP2C19 (0.51) | ALDH1A1LMNAMAPTSMN1; SMN2CYP2C19 | |
| SCHEMBL24214205 | 0.72 | PSMB8 (0.50) | ALDH1A1L3MBTL1HTTLMNAMAPT | |
| SCHEMBL21682157 | 0.71 | PSMB8 (0.69) | ALDH1A1L3MBTL1HTTLMNAMAPT | |
| SCHEMBL31123708 | 0.71 | PSMB8 (0.69) | ALDH1A1L3MBTL1HTTLMNAMAPT | |
| SCHEMBL10047096 | 0.71 | PSMB8 (0.64) | ALDH1A1L3MBTL1HTTLMNAMAPT | |
| SCHEMBL16625012 | 0.71 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1HTTLMNAMAPT | |
| Benzene SCHEMBL28000606 | 0.70 | PSMB8 (0.72) | ALDH1A1L3MBTL1HTTLMNAMAPT | |
| SCHEMBL10700457 | 0.70 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1HTTLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10717743-B2 | Intermediates and methods for the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2020-07-21 | — | — | US | disclosed |
| US-20190263826-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-08-29 | — | — | US | disclosed |
| US-20180037588-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-02-08 | — | — | US | disclosed |
| US-9802953-B2 | Intermediates and methods for the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-10-31 | — | — | US | disclosed |
| US-9604993-B2 | Intermediates and methods for the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-03-28 | — | — | US | disclosed |
| EP-2578576-B9 | Intermediates for the synthesis of halichondrin B analogs | EISAI R&D MAN CO LTD (JP) | 2016-09-14 | — | — | EP | disclosed |
| US-20160214992-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-07-28 | — | — | US | disclosed |
| EP-2578576-B1 | Intermediates for the synthesis of halichondrin B analogs | EISAI R&D MAN CO LTD (JP) | 2016-03-23 | — | — | EP | disclosed |
| US-20150225415-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-08-13 | — | — | US | disclosed |
| US-8987479-B2 | Intermediates and methods for the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-03-24 | — | — | US | disclosed |
| EP-2200992-B1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MAN CO LTD (JP) | 2014-02-26 | — | — | EP | disclosed |
| EP-2578576-A1 | Intermediates for the synthesis of halichondrin B analogs | Eisai R&D Management Co., Ltd. (JP) | 2013-04-10 | — | — | EP | disclosed |
| US-20120095242-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-19 | — | — | US | disclosed |
| US-8093410-B2 | Intermediates and methods for the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-01-10 | — | — | US | disclosed |
| EP-2200992-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | Eisai R&D Management Co., Ltd. (JP) | 2010-06-30 | — | — | EP | disclosed |
| US-20090198074-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI CO., LTD. (JP) | 2009-08-06 | — | — | US | disclosed |
| WO-2009046308-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263826-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | DHPS, LSS, BMP2 | ALDH1A1 2434/4885L3MBTL1 3417/4885HTT 2130/4885 |
| US-10717743-B2 | Intermediates and methods for the synthesis of halichondrin B analogs | DHPS, LSS, BMP2 | ALDH1A1 2434/4885L3MBTL1 3417/4885HTT 2130/4885 |
| US-20160214992-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | DHPS, LSS, BMP2 | ALDH1A1 2434/4885L3MBTL1 3417/4885HTT 2130/4885 |
| US-20180037588-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | DHPS, LSS, BMP2 | ALDH1A1 2434/4885L3MBTL1 3417/4885HTT 2130/4885 |
| US-20120095242-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | DHPS, LSS, BMP2 | ALDH1A1 2434/4885L3MBTL1 3417/4885HTT 2130/4885 |
| US-20150225415-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | DHPS, LSS, BMP2 | ALDH1A1 2434/4885L3MBTL1 3417/4885HTT 2130/4885 |
| US-20090198074-A1 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | DHPS, LSS, BMP2 | ALDH1A1 2434/4885L3MBTL1 3417/4885HTT 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.