Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | TTPA | P49638 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.78 |
| ▸ | USP2 | O75604 | 1/20 | 0.78 |
| ▸ | THRB | P10828 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.71 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.71 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.62 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Tocopherol SCHEMBL28174565 | 0.89 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL28174566 | 0.89 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27538180 | 0.89 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tochopherol SCHEMBL1879635 | 0.89 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL4083978 | 0.89 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27696980 | 0.89 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27177 | 0.89 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL5868266 | 0.88 | LMNA (0.88) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL460611 | 0.88 | LMNA (0.88) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL7584393 | 0.88 | LMNA (0.74) | LMNATTPAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682552-B1 | TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUNDS | SONUS PHARMA INC (US) | 2010-06-30 | — | — | EP | disclosed |
| US-20080045559-A1 | TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUNDS | SONUS PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | US | disclosed |
| US-20070207196-A1 | TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUND FORMULATIONS | SONUS PHARMACEUTICALS, INC. (US) | 2007-09-06 | — | — | US | disclosed |
| US-7223770-B2 | Tocopherol-modified therapeutic drug compounds | SONUS PHARMACEUTICALS, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-20060229359-A1 | Tocopherol-modified therapeutic drug compounds | SONUS PHARMACEUTICALS, INC. (US) | 2006-10-12 | — | — | US | disclosed |
| EP-1682552-A1 | TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUNDS | SONUS PHARMACEUTICALS, INC. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042539-A1 | TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUNDS | SONUS PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |
| US-20050096340-A1 | lipophilic derivatives of paclitaxel, camptothecin, docetaxel or derivatives thereof; tocopherol succinate paclitaxel for example; emulsions for drug delivery, treating cancer; increased plasma elimination half-life compared to the parent therapeutic drug | SONUS PHARMACEUTICALS, INC. | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096340-A1 | lipophilic derivatives of paclitaxel, camptothecin, docetaxel or derivatives thereof; tocopherol succinate paclitaxel for example; emulsions for drug delivery, treating cancer; increased plasma elimination half-life compared to the parent therapeutic drug | TTPA, CPT2, CETP | LMNA 417/4885TTPA 1/4885MAPT 192/4885 |
| US-20060229359-A1 | Tocopherol-modified therapeutic drug compounds | TTPA, APOB, LRAT | LMNA 564/4885TTPA 1/4885MAPT 389/4885 |
| US-20070207196-A1 | TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUND FORMULATIONS | TTPA, APOB, LRAT | LMNA 567/4885TTPA 1/4885MAPT 333/4885 |
| US-20080045559-A1 | TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUNDS | TTPA, APOB, LRAT | LMNA 564/4885TTPA 1/4885MAPT 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.