Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Hymecromone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.87 |
| ▸ | HSD17B3 | P37058 | 8/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.87 |
| ▸ | CA12 | O43570 | 6/20 | 0.87 |
| ▸ | CA9 | Q16790 | 6/20 | 0.87 |
| ▸ | HPGD | P15428 | 4/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.87 |
| ▸ | GAA | P10253 | 4/20 | 0.87 |
| ▸ | GLA | P06280 | 3/20 | 0.87 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.87 |
| ▸ | MAOB | P27338 | 3/20 | 0.87 |
| ▸ | CASP1 | P29466 | 2/20 | 0.87 |
| ▸ | CASP7 | P55210 | 2/20 | 0.87 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.87 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.87 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.87 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hymecromone SCHEMBL29364837 | 0.93 | HSD17B3 (1.00) | HSD17B3ALDH1A1KDM4ECA12CA9 | |
| Hymecromone SCHEMBL24150 | 0.93 | HSD17B3 (1.00) | HSD17B3ALDH1A1KDM4ECA12CA9 | |
| Hymecromone SCHEMBL2357040 | 0.93 | HSD17B3 (1.00) | HSD17B3ALDH1A1KDM4ECA12CA9 | |
| Hymecromone SCHEMBL29624431 | 0.93 | HSD17B3 (1.00) | HSD17B3ALDH1A1KDM4ECA12CA9 | |
| Hymecromone SCHEMBL31014 | 0.92 | HSD17B3 (0.96) | HSD17B3ALDH1A1KDM4ECA12CA9 | |
| Hymecromone SCHEMBL27924142 | 0.92 | HSD17B3 (0.96) | HSD17B3ALDH1A1KDM4ECA12CA9 | |
| Hymecromone SCHEMBL27728511 | 0.90 | HSD17B3 (0.93) | HSD17B3ALDH1A1KDM4ECA12CA9 | |
| Hymecromone SCHEMBL2256610 | 0.89 | ALDH1A1 (0.90) | HSD17B3ALDH1A1KDM4ECA12CA9 | |
| Hymecromone SCHEMBL7594956 | 0.87 | KDM4E (0.87) | HSD17B3ALDH1A1KDM4ECA12CA9 | |
| Hymecromone SCHEMBL28882003 | 0.87 | KDM4E (0.87) | HSD17B3ALDH1A1KDM4ECA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 273 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119224316-B | Detection method and application for botulinum neurotoxin type B | 兰州生物技术开发有限公司 | 2025-05-16 | — | — | CN | claimed |
| CN-119708627-A | Preparation method of nano calcium carbonate with good high temperature resistance and flame retardance dispersibility | 湖北三峡实验室 | 2025-03-28 | — | — | CN | claimed |
| CN-119438162-A | Ce-based3+/Ce4+Fluorescence and colorimetric dual-mode detection method for simultaneously measuring hydrogen peroxide and organic phosphorus by cascade simulated enzyme reaction | 临沂大学 | 2025-02-14 | — | — | CN | claimed |
| CN-119224316-A | Detection method and application for botulinum neurotoxin type B | 兰州生物技术开发有限公司 | 2024-12-31 | — | — | CN | claimed |
| CN-118773000-A | Alkaline phosphatase detection device and method for adipose-derived stem cell osteogenic differentiation | 江苏圣澄干细胞科技有限公司 | 2024-10-15 | — | — | CN | claimed |
| CN-116410310-B | anti-CMLC-1 monoclonal antibody 8A3 and application thereof | 北京普恩光德生物科技开发有限公司 | 2023-10-27 | — | — | CN | claimed |
| CN-116410310-A | anti-CMLC-1 monoclonal antibody 8A3 and application thereof | 北京普恩光德生物科技开发有限公司 | 2023-07-11 | — | — | CN | claimed |
| CN-115478094-A | Enzyme substrate method determination agent for total number of bacterial colonies in water and preparation method thereof | 奎泰斯特(上海)科技有限公司 | 2022-12-16 | — | — | CN | claimed |
| CN-111229193-B | Application of zirconium dioxide nano particles as alkaline phosphatase nano mimics | 重庆师范大学 | 2022-10-18 | — | — | CN | claimed |
| CN-112710644-B | Zymogram method for determining two-dimensional spatial distribution of activity of rhizosphere phosphatase of aquatic plants | 中国科学院南京地理与湖泊研究所 | 2022-04-19 | — | — | CN | claimed |
| WO-2010039899-A2 | METHOD FOR MONITORING INTRACELLULAR TYROSINE PHOSPHATASE ACTIVITY | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2010-04-08 | — | — | WO | claimed |
| US-20100086957-A1 | METHOD FOR MONITORING INTRACELLULAR TYROSINE PHOSPHATASE ACTIVITY | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2010-04-08 | — | — | US | claimed |
| CN-101551333-A | Composition for cell permeabilization comprising NOG, HMP, rubidium chloride and/or lithium chloride for detecting living cells on a membrane | MILLIPORE CORP (US) | 2009-10-07 | — | — | CN | claimed |
| EP-0724015-B1 | Novel alkaline phosphatase, its production and use | TOYO BOSEKI (JP) | 2004-03-31 | — | — | EP | claimed |
| EP-0816514-B1 | Enzyme substrate | TOSOH CORP (JP) | 2003-04-09 | — | — | EP | claimed |
| US-5895819-A | Enzyme substrate | TOSOH CORPORATION (JP) | 1999-04-20 | — | — | US | claimed |
| US-5821061-A | REACTING A LIGAND IN A SAMPLE WITH A SUBSTANCE BONDED WITH A BACILLUS ALKALINE PHOSPHATASE | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1998-10-13 | — | — | US | claimed |
| EP-0816514-A2 | Enzyme substrate | Tosoh Corporation (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0724015-A2 | Novel alkaline phosphatase, its production and use | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1996-07-31 | — | — | EP | claimed |
| US-5055390-A | Amphiphilic compound migrating into droplet, interacting with biological entity; measuring fluorescence | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1991-10-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100086957-A1 | METHOD FOR MONITORING INTRACELLULAR TYROSINE PHOSPHATASE ACTIVITY | PTPRCAP, PTPRC, PTPA | KDR 2569/4885HSD17B3 4181/4885ALDH1A1 3727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.