Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 3/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SELL | P14151 | 1/20 | 0.44 |
| ▸ | SELP | P16109 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30848253 | 0.83 | ALDH1A1 (0.53) | HNF4AMMP2ACMSDKMT2AKDM4E | |
| SCHEMBL14689993 | 0.81 | HNF4A (0.55) | HNF4AMMP2ACMSDLDHAKMT2A | |
| SCHEMBL27740047 | 0.81 | KMT2A (0.46) | HNF4AMMP2ACMSDKMT2AKDM4E | |
| SCHEMBL11026751 | 0.81 | HNF4A (0.58) | HNF4AACMSDLDHAKDM4ESELL | |
| SCHEMBL28318563 | 0.80 | HSD17B10 (0.43) | MMP2KMT2AKDM4EIKBKBIDO1 | |
| SCHEMBL3884497 | 0.79 | KMT2A (0.47) | HNF4AMMP2ACMSDKMT2AKDM4E | |
| SCHEMBL8001214 | 0.79 | HNF4A (0.67) | HNF4AACMSDLDHASELLSELP | |
| SCHEMBL2946213 | 0.79 | KMT2A (0.47) | HNF4AACMSDKMT2AKDM4EGFER | |
| SCHEMBL6537038 | 0.79 | HNF4A (0.71) | HNF4AACMSDLDHAKDM4ESELL | |
| SCHEMBL1162152 | 0.78 | MMP2 (0.57) | HNF4AMMP2LDHAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4036951-A | SUNSCREEN AGENTS | SYNERGISTICS, INC. (US) | 1977-07-19 | — | — | US | claimed |
| US-7691896-B2 | Analogs of salinosporamide A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-04-06 | — | — | US | disclosed |
| EP-1931679-A4 | ANALOGS OF SALINOSPORAMIDE A | HARVARD COLLEGE (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20090054665-A1 | ANALOGS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-02-26 | — | — | US | disclosed |
| EP-1931679-A1 | ANALOGS OF SALINOSPORAMIDE A | The President and Fellows of Harvard College (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021897-A1 | ANALOGS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-02-22 | — | — | WO | disclosed |
| WO-2005085189-A2 | ANALOGUES OF CONGO RED AND EVALUATION OF THEIR ANTI-PRION ACTIVITY | MEDICAL RESEARCH COUNCIL (GB) | 2005-09-15 | — | — | WO | disclosed |
| US-6326417-B1 | CONTAINING SALICYLIC ACID COMPOUND AS MICROBIOCIDES | JENERIC/PENTRON INCORPORATED | 2001-12-04 | — | — | US | disclosed |
| US-6297239-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1021188-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999017777-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |
| US-5646098-A | Carbonyl containing compounds and their derivatives as multi-functional fuel and lube additives | EXXON CHEMICAL PATENTS INC (US) | 1997-07-08 | — | — | US | disclosed |
| US-4036951-A | SUNSCREEN AGENTS | SYNERGISTICS, INC. (US) | 1977-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054665-A1 | ANALOGS OF SALINOSPORAMIDE A | PSME1, PSMG3, PSMD5 | HNF4A 4240/4885MMP2 3716/4885ACMSD 4364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.