Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3191980 | 0.79 | LOXL2 (0.48) | LOXL2F10HDAC3NCOR2HDAC6 | |
| SCHEMBL422913 | 0.75 | LOXL2 (0.65) | LOXL2F10HDAC3NCOR2HDAC6 | |
| SCHEMBL23179867 | 0.73 | HSD11B1 (0.45) | LOXL2HDAC3NCOR2HDAC6NR1H2 | |
| SCHEMBL8139521 | 0.73 | TPSAB1 (0.47) | LOXL2HDAC3NCOR2NR1H2HDAC1 | |
| SCHEMBL12219494 | 0.73 | LOXL2 (0.41) | LOXL2HDAC3NCOR2HDAC6NR1H2 | |
| SCHEMBL16856539 | 0.73 | PAX8 (0.49) | LOXL2HDAC3NCOR2HDAC6NR1H2 | |
| SCHEMBL5731734 | 0.72 | LOXL2 (0.49) | LOXL2F10HDAC3NCOR2HDAC6 | |
| SCHEMBL27574383 | 0.72 | LOXL2 (0.51) | LOXL2F10HDAC3NCOR2HDAC6 | |
| Hydrochloric Acid SCHEMBL5846568 | 0.71 | LOXL2 (0.47) | LOXL2F10HDAC3NCOR2HDAC6 | |
| Acetic Acid SCHEMBL9708933 | 0.71 | LOXL2 (0.59) | LOXL2F10HDAC3NCOR2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087491-A1 | POLYCYCLIC COMPOUNDS | NOVARTIS AG (CH) | 2010-04-08 | — | — | US | disclosed |
| EP-2081916-A1 | OXADIAZOLE DERIVATIVES WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE PROPERTIES | Novartis AG (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008037476-A1 | OXADIAZOLE DERIVATIVES WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE PROPERTIES | NOVARTIS AG (CH) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087491-A1 | POLYCYCLIC COMPOUNDS | CD4, HLA-DRB1, MALT1 | LOXL2 1749/4885F10 2665/4885HDAC3 3020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.