Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 7/20 | 0.50 |
| ▸ | GRM5 | P41594 | 5/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13606452 | 0.87 | GRM5 (0.53) | PGRGRM5MAP4K4AR | |
| SCHEMBL13606239 | 0.86 | GABRG2 (0.55) | PGRGRM5MAP4K4AR | |
| SCHEMBL13606092 | 0.86 | GABRG2 (0.55) | PGRGRM5MAP4K4AR | |
| SCHEMBL13606338 | 0.86 | MAP4K4 (0.51) | PGRGRM5MAP4K4AR | |
| SCHEMBL1543177 | 0.85 | TSHR (0.55) | TSHR | |
| SCHEMBL1191520 | 0.85 | TSHR (0.55) | GRM5TSHR | |
| SCHEMBL21887886 | 0.84 | GRM5 (0.54) | GRM5TSHR | |
| SCHEMBL29914895 | 0.83 | TSHR (0.52) | GRM5TSHR | |
| SCHEMBL20843323 | 0.81 | GRM5 (0.52) | GRM5 | |
| Benzonitrile SCHEMBL28071141 | 0.81 | TSHR (0.64) | PGRGRM5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004417-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | NATIONAL SCIENCE FOUNDATION | 2012-01-05 | — | — | US | disclosed |
| US-20110190505-A1 | Iodonium Cyclophanes for SECURE Arene Functionalization | NATIONAL SCIENCE FOUNDATION | 2011-08-04 | — | — | US | disclosed |
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004417-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | PFAS, SLC43A1, DDC | PGR 4349/4885GRM5 3724/4885MAP4K4 1060/4885 |
| US-20110190505-A1 | Iodonium Cyclophanes for SECURE Arene Functionalization | ABL1, SLC7A5, DDC | PGR 4038/4885GRM5 743/4885MAP4K4 1275/4885 |
| US-20090306115-A1 | Phenyl ethyne compounds | DDT, CHRM3, CBR3 | PGR 263/4885GRM5 143/4885MAP4K4 1613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.