SCHEMBL3277091

SCHEMBL3277091

FC(F)(F)c1ccn(-c2ncccc2C(F)(F)F)n1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.48
HSD11B1 P28845 13/20 0.43
KDM4E B2RXH2 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
GAA P10253 1/20 0.39
MAPT P10636 2/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL535692 0.83 KDM4E (0.40) HSD11B1KDM4EL3MBTL1NPC1RAB9A
SCHEMBL17023407 0.83 EPHX2 (0.47) EPHX2HSD11B1KDM4EL3MBTL1NPC1
SCHEMBL22421823 0.79 MAPT (0.44) KDM4EL3MBTL1NPC1RAB9AMAPT
SCHEMBL8149940 0.78 IDH1 (0.44) NPC1RAB9AMAPT
SCHEMBL30361915 0.77 CAPN1 (0.46) KDM4EL3MBTL1NPC1RAB9AMAPT
SCHEMBL28324866 0.77 EPHX2 (0.50) EPHX2HSD11B1GAAMAPTMEN1
SCHEMBL6449976 0.76 EPHX2 (0.41) EPHX2HSD11B1KDM4EGAAMEN1
SCHEMBL28877061 0.75 EPHX2 (0.49) EPHX2HSD11B1GAAMAPT
SCHEMBL2733207 0.74 MAPT (0.33) EPHX2HSD11B1KDM4EL3MBTL1NPC1
SCHEMBL21571872 0.74 KDM4E (0.40) KDM4EL3MBTL1NPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9173400-B2 Anthranilamide arthropodicide treatment E I DU PONT DE NEMOURS AND COMPANY (US) 2015-11-03 US disclosed
US-9113630-B2 Method of controlling particular insect pests by applying anthranilamide compounds E I DU PONT DE NEMOURS AND COMPANY (US) 2015-08-25 US disclosed
US-20140141972-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E I DU PONT NEMOURS AND COMPANY (US) 2014-05-22 US disclosed
US-20140140973-A1 METHOD OF CONTROLLING PARTICULAR INSECT PESTS BY APPLYNG ANTHRANILAMIDE COMPOUNDS E I DU PONT DE NEMOURS AND COMPANY (US) 2014-05-22 US disclosed
US-8697734-B2 Method for controlling particular insect pests by applying anthranilamide compounds E I DU PONT DE NEMOURS AND COMPANY (US) 2014-04-15 US disclosed
US-8637552-B2 Anthranilamide arthropodicide treatment E I DU PONT DE NEMOURS AND COMPANY (US) 2014-01-28 US disclosed
US-20130028879-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E I DU PONT DE NEMOURS AND COMPANY (US) 2013-01-31 US disclosed
US-20130031677-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E I DU PONT DE NEMOURS AND COMPANY (US) 2013-01-31 US disclosed
US-20100160307-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-06-24 US disclosed
US-20100152194-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-06-17 US disclosed
US-20080275061-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS FMC CORPORATION 2008-11-06 US disclosed
US-7338978-B2 Insecticidal anthranilamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-03-04 US disclosed
EP-1427285-B1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT DU PONT (US) 2007-08-22 EP disclosed
EP-1265850-B1 INSECTICIDAL ANTHRANILAMIDES DU PONT (US) 2007-01-03 EP disclosed
EP-1700845-A1 Insecticidal anthranilamides E.I.Du pont de nemours and company (US) 2006-09-13 EP disclosed
US-20060079561-A1 Insecticidal anthranilamides FMC CORPORATION 2006-04-13 US disclosed
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds E. I. DU PONT DE NEMOURS AND COMPANY 2005-04-07 US disclosed
US-20040209923-A1 Anthranilamide arthropodicide treatment FMC CORPORATION 2004-10-21 US disclosed
US-6747047-B2 ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY 2004-06-08 US disclosed
US-20030229050-A1 Insecticidal anthranilamides FMC CORPORATION 2003-12-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100160307-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS ANTXR2, HRH4, HDAC10 EPHX2 1941/4885HSD11B1 3218/4885KDM4E 309/4885
US-20140140973-A1 METHOD OF CONTROLLING PARTICULAR INSECT PESTS BY APPLYNG ANTHRANILAMIDE COMPOUNDS ANTXR2, NIT2, TDO2 EPHX2 1944/4885HSD11B1 3524/4885KDM4E 415/4885
US-20130031677-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT ANTXR2, ARF5, NPR1 EPHX2 2997/4885HSD11B1 4745/4885KDM4E 3625/4885
US-20040209923-A1 Anthranilamide arthropodicide treatment ANTXR2, ARF5, NPM1 EPHX2 2927/4885HSD11B1 4631/4885KDM4E 3875/4885
US-20060079561-A1 Insecticidal anthranilamides ANTXR2, CYB5R3, NIT2 EPHX2 795/4885HSD11B1 2374/4885KDM4E 1284/4885
US-20030229050-A1 Insecticidal anthranilamides ANTXR2, NIT2, CYB5R3 EPHX2 913/4885HSD11B1 2601/4885KDM4E 1313/4885
US-20130028879-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS ANTXR2, CYP4X1, PRDX1 EPHX2 677/4885HSD11B1 2034/4885KDM4E 285/4885
US-20100152194-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT ANTXR2, ARF5, NPR1 EPHX2 2997/4885HSD11B1 4745/4885KDM4E 3625/4885
US-20080275061-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS ANTXR2, HRH4, HDAC10 EPHX2 1941/4885HSD11B1 3218/4885KDM4E 309/4885
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds ANTXR2, HRH4, HDAC10 EPHX2 2092/4885HSD11B1 3276/4885KDM4E 276/4885
US-20140141972-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT ANTXR2, ARF5, NPR1 EPHX2 2997/4885HSD11B1 4745/4885KDM4E 3625/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.