Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 3/20 | 0.38 |
| ▸ | ACACA | Q13085 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5250106 | 1.00 | ACACB (0.38) | ACACBACACAGAAALOX12SMN1; SMN2 | |
| SCHEMBL3279286 | 0.96 | L3MBTL3 (0.38) | ACACBACACAGAAALOX12SMN1; SMN2 | |
| SCHEMBL3278543 | 0.92 | GAA (0.41) | ACACBACACAGAAALOX12SMN1; SMN2 | |
| SCHEMBL3282738 | 0.90 | KRAS (0.34) | ACACBACACAALDH1A1KDM4EHRH3 | |
| SCHEMBL3279106 | 0.89 | ITGB3 (0.39) | GAAALOX12SMN1; SMN2L3MBTL3L3MBTL1 | |
| SCHEMBL3284870 | 0.86 | CCR5 (0.41) | ACACBACACAGAAALOX12SMN1; SMN2 | |
| SCHEMBL3285188 | 0.86 | CCR5 (0.41) | ACACBACACAGAAALOX12SMN1; SMN2 | |
| SCHEMBL3285679 | 0.85 | L3MBTL3 (0.39) | L3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL5249986 | 0.83 | CCR3 (0.37) | ACACBACACAGAAALOX12SMN1; SMN2 | |
| SCHEMBL4718312 | 0.83 | CCR5 (0.39) | ACACBACACAGAAALOX12SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152171-A1 | CGRP Antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-06-17 | — | — | US | disclosed |
| US-7700589-B2 | CGRP antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-04-20 | — | — | US | disclosed |
| US-20070244099-A1 | CGRP Antagonists | RUDOLF KLAUS | 2007-10-18 | — | — | US | disclosed |
| US-20040132716-A1 | CGRP antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244099-A1 | CGRP Antagonists | CALCRL, OPRL1, CALCA | ACACB 4685/4885ACACA 4193/4885GAA 4211/4885 |
| US-20100152171-A1 | CGRP Antagonists | CALCRL, OPRL1, CALCA | ACACB 4685/4885ACACA 4193/4885GAA 4211/4885 |
| US-20040132716-A1 | CGRP antagonists | OPRL1, HTR1D, CALCA | ACACB 4846/4885ACACA 4484/4885GAA 4270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.