Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328388 | 0.91 | MMP3 (0.43) | MMP3POLBGAAMMP1MMP7 | |
| SCHEMBL328400 | 0.89 | MMP3 (0.51) | ALDH1A1LMNAMMP3MAPTSMN1; SMN2 | |
| SCHEMBL328557 | 0.88 | ADRB2 (0.43) | ADRB2ALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL6852303 | 0.82 | ADRB2 (0.38) | ADRB2ALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL6864692 | 0.82 | MMP3 (0.50) | ALDH1A1LMNAMMP3MAPTSMN1; SMN2 | |
| SCHEMBL328554 | 0.81 | MMP3 (0.48) | ALDH1A1LMNAKMT2AMEN1MMP3 | |
| SCHEMBL6863158 | 0.81 | MMP3 (0.43) | LMNAMMP3MMP1MMP7MMP8 | |
| SCHEMBL328412 | 0.81 | MMP3 (0.37) | KMT2AMEN1MMP3HPGD | |
| SCHEMBL10067173 | 0.81 | MMP3 (0.49) | MMP3MMP1MMP7MMP8MMP12 | |
| SCHEMBL328413 | 0.80 | MMP3 (0.51) | MMP3MMP1MMP7MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |