Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
| ▸ | BMP1 | P13497 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328488 | 0.93 | MMP3 (0.42) | MMP3BMP1ALDH1A1MAPTLMNA | |
| SCHEMBL328400 | 0.93 | MMP3 (0.51) | MMP3BMP1ALDH1A1MAPTLMNA | |
| SCHEMBL328554 | 0.90 | MMP3 (0.48) | MMP3BMP1ALDH1A1MAPTLMNA | |
| SCHEMBL328480 | 0.87 | MMP3 (0.47) | MMP3BMP1ALDH1A1MAPTLMNA | |
| SCHEMBL328555 | 0.86 | MMP3 (0.53) | MMP3BMP1ALDH1A1MAPTMMP2 | |
| SCHEMBL328492 | 0.85 | MMP1 (0.42) | MMP3BMP1MMP2MMP9MMP1 | |
| SCHEMBL328388 | 0.85 | MMP3 (0.43) | MMP3BMP1MMP2MMP9MMP1 | |
| SCHEMBL6864658 | 0.83 | MMP3 (0.46) | MMP3BMP1ALDH1A1MAPTLMNA | |
| SCHEMBL10067178 | 0.82 | MMP3 (0.50) | MMP3KDM4E | |
| SCHEMBL328401 | 0.82 | ADRB2 (0.43) | MMP3ALDH1A1MAPTLMNAMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |