Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | AHCY | P23526 | 6/20 | 0.35 |
| ▸ | USP14 | P54578 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852303 | 0.89 | ADRB2 (0.38) | KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL6852333 | 0.87 | MMP3 (0.39) | MMP3KEAP1NFE2L2F10AHCY | |
| SCHEMBL328551 | 0.87 | ALDH1A1 (0.36) | MMP3F10HPGDMEN1KMT2A | |
| SCHEMBL6852594 | 0.86 | AHCY (0.44) | MMP3AHCYEPHX2 | |
| SCHEMBL6852386 | 0.86 | MMP3 (0.38) | MMP3KEAP1NFE2L2F10AHCY | |
| SCHEMBL328556 | 0.85 | MMP3 (0.40) | MMP3KEAP1NFE2L2F10AHCY | |
| SCHEMBL6852329 | 0.83 | ALDH1A1 (0.41) | MMP2MMP9HPGDMEN1KMT2A | |
| SCHEMBL328388 | 0.83 | MMP3 (0.43) | MMP3MMP2MMP9 | |
| SCHEMBL328488 | 0.83 | MMP3 (0.42) | MMP3KEAP1NFE2L2MMP2MMP9 | |
| SCHEMBL6852266 | 0.83 | HRH3 (0.36) | SOS1MMP2MMP9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |