Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 6/20 | 0.40 |
| ▸ | MMP1 | P03956 | 6/20 | 0.39 |
| ▸ | MMP13 | P45452 | 6/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.37 |
| ▸ | MMP7 | P09237 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | MMP16 | P51512 | 1/20 | 0.37 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852592 | 0.91 | CHRM5 (0.35) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL328388 | 0.85 | MMP3 (0.43) | MMP3MMP1MMP13MMP9ADAM17 | |
| SCHEMBL10067173 | 0.83 | MMP3 (0.49) | MMP3MMP1MMP13MMP9ADAM17 | |
| SCHEMBL328413 | 0.83 | MMP3 (0.51) | MMP3MMP1MMP13MMP9ADAM17 | |
| SCHEMBL6865083 | 0.82 | MMP1 (0.48) | MMP3MMP1MMP13MMP9MEP1B | |
| SCHEMBL6864863 | 0.81 | MMP2 (0.45) | MMP3MMP1MMP13MMP9ADAM17 | |
| SCHEMBL328404 | 0.81 | BMP1 (0.43) | MMP3MMP1MMP13MMP9MEP1B | |
| SCHEMBL10067178 | 0.81 | MMP3 (0.50) | MMP3 | |
| SCHEMBL328560 | 0.81 | MMP3 (0.44) | MMP3MMP1MMP13MMP9ADAM17 | |
| SCHEMBL328554 | 0.81 | MMP3 (0.48) | MMP3MMP1MMP13MMP9MEP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |