Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850926 | 0.94 | POLB (0.46) | MEN1KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL328415 | 0.91 | RXFP1 (0.42) | MEN1KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL10067175 | 0.91 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1L3MBTL1LMNA | |
| SCHEMBL6864106 | 0.90 | MMP3 (0.50) | MEN1KMT2AMAPK1TSHRALDH1A1 | |
| SCHEMBL328403 | 0.90 | MEN1 (0.40) | MEN1KMT2AMAPK1TSHRALDH1A1 | |
| SCHEMBL328406 | 0.84 | MMP3 (0.49) | MEN1KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL6865718 | 0.80 | MMP3 (0.58) | MEN1KMT2AALDH1A1L3MBTL1LMNA | |
| SCHEMBL6852266 | 0.74 | HRH3 (0.36) | KMT2AL3MBTL1 | |
| SCHEMBL328554 | 0.74 | MMP3 (0.48) | MEN1KMT2AALDH1A1L3MBTL1LMNA | |
| SCHEMBL328488 | 0.72 | MMP3 (0.42) | MAPK1ALDH1A1HTTL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |