Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 6/20 | 0.58 |
| ▸ | MMP1 | P03956 | 4/20 | 0.52 |
| ▸ | MMP8 | P22894 | 3/20 | 0.52 |
| ▸ | MMP13 | P45452 | 3/20 | 0.52 |
| ▸ | MMP7 | P09237 | 2/20 | 0.52 |
| ▸ | MMP12 | P39900 | 2/20 | 0.52 |
| ▸ | BMP1 | P13497 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP16 | P51512 | 1/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864106 | 0.91 | MMP3 (0.50) | MMP3MMP1MMP8MMP13MMP7 | |
| SCHEMBL10067175 | 0.89 | ALDH1A1 (0.45) | MMP3BMP1ALDH1A1GAAMAPT | |
| SCHEMBL328406 | 0.84 | MMP3 (0.49) | MMP3MMP1MMP8MMP13MMP7 | |
| SCHEMBL328554 | 0.84 | MMP3 (0.48) | MMP3MMP1MMP8MMP13MMP7 | |
| SCHEMBL328417 | 0.80 | MEN1 (0.43) | MMP3ALDH1A1GAAMAPTLMNA | |
| SCHEMBL328403 | 0.80 | MEN1 (0.40) | MMP3BMP1ALDH1A1GAAMAPT | |
| SCHEMBL13899087 | 0.79 | MMP3 (0.60) | MMP3MMP1MMP8MMP13MMP7 | |
| SCHEMBL328558 | 0.78 | MMP3 (0.43) | MMP3MMP1MMP8MMP13MMP7 | |
| SCHEMBL13899034 | 0.78 | L3MBTL1 (0.61) | MMP3MMP1MMP8MMP13MMP7 | |
| SCHEMBL10067174 | 0.77 | MMP1 (0.54) | MMP3MMP1MMP8MMP13MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |