Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14019668 | 0.89 | CNR1 (0.39) | KDM4ELMNAHTTALDH1A1HPGD | |
| SCHEMBL3294927 | 0.82 | LMNA (0.52) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL4149665 | 0.81 | LMNA (0.54) | KDM4ELMNAHTTALDH1A1HPGD | |
| SCHEMBL10864501 | 0.80 | LMNA (0.55) | KDM4ELMNAALDH1A1CNR2 | |
| SCHEMBL4141571 | 0.79 | KDM4E (0.41) | KDM4ELMNAHTTALDH1A1HPGD | |
| SCHEMBL7845781 | 0.79 | TSHR (0.42) | KDM4ELMNAALDH1A1HSD17B10TSHR | |
| SCHEMBL3767466 | 0.78 | KDM4E (0.51) | KDM4ELMNAHTTALDH1A1HPGD | |
| SCHEMBL4144523 | 0.78 | ALDH1A1 (0.48) | KDM4ELMNAHTTALDH1A1HPGD | |
| SCHEMBL4150175 | 0.78 | KDM4E (0.42) | KDM4ELMNAHTTALDH1A1HPGD | |
| SCHEMBL4154022 | 0.78 | KDM4E (0.42) | KDM4ELMNAHTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718621-B2 | Macrolones—amino substituted quinolones | GLAXO GROUP LTD. (GB) | 2010-05-18 | — | — | US | disclosed |
| US-20090170791-A1 | MACROLONES | GLAXO SMITH KLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O A CORPORATION | 2009-07-02 | — | — | US | disclosed |
| US-20090170791-A1 | MACROLONES | GLAXO SMITH KLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O A CORPORATION | 2009-07-02 | — | — | US | disclosed |
| US-20090170791-A1 | MACROLONES | GLAXO SMITH KLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O A CORPORATION | 2009-07-02 | — | — | US | disclosed |
| US-7547679-B2 | Ether linked macrolides useful for the treatment of microbial infections | GLAXOSMITHKLINE ISTRAZIVACKI CENTER ZAGREB D.O.O (HR) | 2009-06-16 | — | — | US | disclosed |
| US-7547679-B2 | Ether linked macrolides useful for the treatment of microbial infections | GLAXOSMITHKLINE ISTRAZIVACKI CENTER ZAGREB D.O.O (HR) | 2009-06-16 | — | — | US | disclosed |
| US-7547679-B2 | Ether linked macrolides useful for the treatment of microbial infections | GLAXOSMITHKLINE ISTRAZIVACKI CENTER ZAGREB D.O.O (HR) | 2009-06-16 | — | — | US | disclosed |
| US-20090062218-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| US-20080312167-A1 | 4'' Amino Linked Macrolides Useful for the Treatment of Microbial Infections | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR (HR) | 2008-12-18 | — | — | US | disclosed |
| US-20080312167-A1 | 4'' Amino Linked Macrolides Useful for the Treatment of Microbial Infections | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR (HR) | 2008-12-18 | — | — | US | disclosed |
| US-20080312167-A1 | 4'' Amino Linked Macrolides Useful for the Treatment of Microbial Infections | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR (HR) | 2008-12-18 | — | — | US | disclosed |
| EP-1945652-A1 | MACROLONES | GLAXO GROUP LIMITED (GB) | 2008-07-23 | — | — | EP | disclosed |
| US-20080090773-A1 | Macrolones - Amino Substituted Quinolones | GLAXO GROUP LIMITED (GB) | 2008-04-17 | — | — | US | disclosed |
| EP-1879904-A1 | 4\" AMINO LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2008-01-23 | — | — | EP | disclosed |
| CN-101098881-A | Macrolones - amino substituted quinolones | GLAXO GROUP LTD (GB) | 2008-01-02 | — | — | CN | disclosed |
| EP-1824870-A1 | MACROLONES - AMINO SUBSTITUTED QUINOLONES | GLAXO GROUP LIMITED (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2007054296-A1 | MACROLONES | GLAXO GROUP LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |
| WO-2006120545-A1 | 4' AMINO LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2006-11-16 | — | — | WO | disclosed |
| US-20060258600-A1 | 14- or 15-Membered macrolides substituted at the 4'' position such as 4''-O-[2-(2-{2-[2-(3-Carboxy-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinolin-6-ylamino)-ethoxy]-ethoxy}-ethylamino)-ethyl]-azithromycin 11,12-cyclic carbonate; therapy or prophylaxis of systemic or topical microbial infections | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-11-16 | — | — | US | disclosed |
| WO-2006050942-A1 | MACROLONES - AMINO SUBSTITUTED QUINOLONES | GLAXO GROUP LIMITED (GB) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258600-A1 | 14- or 15-Membered macrolides substituted at the 4'' position such as 4''-O-[2-(2-{2-[2-(3-Carboxy-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinolin-6-ylamino)-ethoxy]-ethoxy}-ethylamino)-ethyl]-azithromycin 11,12-cyclic carbonate; therapy or prophylaxis of systemic or topical microbial infections | IL17A, IL15, CASP14 | KDM4E 1422/4885LMNA 3341/4885HTT 4022/4885 |
| US-20090062218-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | KDM4E 3897/4885LMNA 1055/4885HTT 2204/4885 |
| US-20080312167-A1 | 4'' Amino Linked Macrolides Useful for the Treatment of Microbial Infections | IL4I1, IL4, TLR5 | KDM4E 1535/4885LMNA 3546/4885HTT 3585/4885 |
| US-20080090773-A1 | Macrolones - Amino Substituted Quinolones | MRPL21, Q6ZSR9, QARS1 | KDM4E 2889/4885LMNA 1318/4885HTT 2493/4885 |
| US-20090170791-A1 | MACROLONES | CYP51A1, MRPL21, LSS | KDM4E 4180/4885LMNA 1071/4885HTT 2622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.