Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30545060 | 0.92 | PCSK9 (0.48) | PCSK9LTA4HALDH1A1TSHRCYP3A4 | |
| SCHEMBL30545064 | 0.92 | PCSK9 (0.48) | PCSK9LTA4HALDH1A1TSHRCYP3A4 | |
| SCHEMBL11711998 | 0.92 | PCSK9 (0.48) | PCSK9LTA4HALDH1A1TSHRCYP3A4 | |
| SCHEMBL14983388 | 0.89 | LTA4H (0.42) | PCSK9LTA4HCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1677080 | 0.88 | PCSK9 (0.42) | PCSK9LTA4HCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7796509 | 0.87 | MEN1 (0.42) | PCSK9LTA4HCYP1A2ALDH1A1TSHR | |
| SCHEMBL14983385 | 0.84 | MGLL (0.44) | PCSK9LTA4HCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14983499 | 0.84 | CA1 (0.45) | PCSK9LTA4HALDH1A1L3MBTL1HPGD | |
| SCHEMBL7799309 | 0.83 | TSHR (0.59) | PCSK9LTA4HCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL18304616 | 0.83 | PCSK9 (0.41) | PCSK9LTA4HCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0692033-A1 | ENHANCEMENT OF CHEMILUMINESCENT REACTIONS | BTG INTERNATIONAL LIMITED (GB) | 1996-01-17 | — | — | EP | claimed |
| WO-2023038506-A1 | COMPOSITION CONTAINING FOXTAIL EXTRACT AS ACTIVE INGREDIENT, AND USE THEREOF | 경북대학교 산학협력단 | 2023-03-16 | — | — | WO | disclosed |
| US-8945820-B2 | Silicon-containing resist underlayer film-forming composition and patterning process | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2015-02-03 | — | — | US | disclosed |
| US-8945820-B2 | Silicon-containing resist underlayer film-forming composition and patterning process | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2015-02-03 | — | — | US | disclosed |
| US-20130137271-A1 | SILICON-CONTAINING RESIST UNDERLAYER FILM-FORMING COMPOSITION AND PATTERNING PROCESS | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2013-05-30 | — | — | US | disclosed |
| US-20130137271-A1 | SILICON-CONTAINING RESIST UNDERLAYER FILM-FORMING COMPOSITION AND PATTERNING PROCESS | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2013-05-30 | — | — | US | disclosed |
| US-8404731-B2 | Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors | TRANSTECH PHARMA, INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-20120196906-A1 | Substituted Imidazole Derivatives, Compositions, and Methods of Use as PTPase Inhibitors | TRANSTECH PHARMA, INC. (US) | 2012-08-02 | — | — | US | disclosed |
| US-7723369-B2 | Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20100113331-A1 | Substituted Imidazole Derivatives, Compositions, and Methods of Use as PtPase Inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| US-20050176987-A1 | Method for producing vinyl, aryl and heteroaryl acetic acids and derivatives thereof | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2005-08-11 | — | — | US | disclosed |
| EP-0968158-B1 | METHOD OF PREPARING SUBSTITUTED INDANONES, THE SUBSTITUTED INDANONES AND METALLOCENES PREPARED THEREFROM | BASELL POLYOLEFINE GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| US-20050033076-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2005-02-10 | — | — | US | disclosed |
| US-20030009046-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2003-01-09 | — | — | US | disclosed |
| EP-0808849-B1 | Process for the production of ethylenic polymers | SHOWA DENKO KK (JP) | 2001-12-19 | — | — | EP | disclosed |
| US-6011127-A | CATALYST COMPRISING A CHROMIUM COMPOUND, AN ALUMOXANE AND AN ORGANOMETALLIC ALKOXIDE AND/OR ORGANOMETALLIC SILOXIDE AND A CARRIER SUPPORTING THEREON THESE COMPOUNDS. | SHOWA DENKO K.K. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0808849-A1 | Process for the production of ethylenic polymers | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1997-11-26 | — | — | EP | disclosed |
| EP-0626016-A1 | CHEMILUMINESCENT ENHANCERS | BTG INTERNATIONAL LIMITED (GB) | 1994-11-30 | — | — | EP | disclosed |
| US-4933421-A | QUICK-CURING | SHELL OIL COMPANY (US) | 1990-06-12 | — | — | US | disclosed |
| US-4085090-A | Aromatic polymers containing a nitrogen-containing ring group, and process for preparation thereof | TEIJIN LIMITED (JA) | 1978-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176987-A1 | Method for producing vinyl, aryl and heteroaryl acetic acids and derivatives thereof | HDHD5, PAH, AHR | PCSK9 4289/4885LTA4H 2481/4885CYP1A2 206/4885 |
| US-20100113331-A1 | Substituted Imidazole Derivatives, Compositions, and Methods of Use as PtPase Inhibitors | PTP4A1, PTPRJ, PTP4A2 | PCSK9 1139/4885LTA4H 1653/4885CYP1A2 1218/4885 |
| US-20050033076-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP2J2, IDH3A | PCSK9 3742/4885LTA4H 3537/4885CYP1A2 1/4885 |
| US-20030009046-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP1B1, CYP1A1 | PCSK9 3869/4885LTA4H 3535/4885CYP1A2 1/4885 |
| US-20120196906-A1 | Substituted Imidazole Derivatives, Compositions, and Methods of Use as PTPase Inhibitors | PTP4A1, PTPRJ, PTP4A2 | PCSK9 1139/4885LTA4H 1653/4885CYP1A2 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.