Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Stanozolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.48 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | SHBG | P04278 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stanozolol SCHEMBL12417517 | 0.85 | CYP2C19 (0.64) | LMNAMAPTCYP2C19ADORA3ESR1 | |
| Stanozolol SCHEMBL19645424 | 0.85 | CYP2C19 (0.64) | LMNAMAPTCYP2C19ADORA3ESR1 | |
| Stanozolol SCHEMBL6151066 | 0.85 | CYP2C19 (0.64) | LMNAMAPTCYP2C19ADORA3ESR1 | |
| Stanozolol SCHEMBL44099 | 0.85 | CYP2C19 (0.64) | LMNAMAPTCYP2C19ADORA3ESR1 | |
| Methandrostenolone SCHEMBL8408550 | 0.79 | LMNA (1.00) | LMNAMAPTCYP19A1GUSBSHBG | |
| Methandrostenolone SCHEMBL4435272 | 0.79 | LMNA (1.00) | LMNAMAPTCYP19A1GUSBSHBG | |
| Methandrostenolone SCHEMBL21177905 | 0.79 | LMNA (1.00) | LMNAMAPTCYP19A1GUSBSHBG | |
| Methandrostenolone SCHEMBL28423591 | 0.79 | LMNA (1.00) | LMNAMAPTCYP19A1GUSBSHBG | |
| Methandrostenolone SCHEMBL16755284 | 0.79 | LMNA (1.00) | LMNAMAPTCYP19A1GUSBSHBG | |
| Methandrostenolone SCHEMBL140928 | 0.79 | LMNA (1.00) | LMNAMAPTCYP19A1GUSBSHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8147561-B2 | Methods and devices to curb appetite and/or reduce food intake | ENDOSPHERE, INC. (US) | 2012-04-03 | — | — | US | claimed |
| US-20110295337-A1 | Systems and Methods For Regulating Metabolic Hormone Producing Tissue | ETHICON ENDO-SURGERY, INC. | 2011-12-01 | — | — | US | claimed |
| EP-1968685-A2 | METHODS AND DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE | Endosphere, Inc. (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007075396-A2 | METHODS AND DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE | ENDOSPHERE, INC. (US) | 2007-07-05 | — | — | WO | claimed |
| US-20060178691-A1 | Methods and devices to curb appetite and/or reduce food intake | THE DIRECTOR OF DEVELOPMENT OF THE STATE OF OHIO | 2006-08-10 | — | — | US | claimed |
| EP-1968685-B1 | DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE | ENDOSPHERE INC (US) | 2018-08-29 | — | — | EP | disclosed |
| US-9795693-B2 | Drug carrier providing MRI contrast enhancement | KONINKLIJKE PHILIPS N.V. (NL) | 2017-10-24 | — | — | US | disclosed |
| EP-2720999-B1 | NOVEL LIPIDOMIMETIC COMPOUNDS AND USES THEREOF | KONINKLIJKE PHILIPS NV (NL) | 2017-08-23 | — | — | EP | disclosed |
| US-9718929-B2 | Chelating amphiphilic polymers | KONINKLIJKE PHILIPS N.V. (NL) | 2017-08-01 | — | — | US | disclosed |
| US-9642802-B2 | Lipid bilayer carrier for drugs or imaging agents | KONINKLIJKE PHILIPS N.V. (NL) | 2017-05-09 | — | — | US | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| US-9352126-B2 | Methods and devices to curb appetite and/or reduce food intake | ENDOSPHERE, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| WO-2002080993-A2 | COATING FOR MEDICAL DEVICES | CHIENNA B.V. (NL) | 2002-10-17 | — | — | WO | disclosed |
| EP-1247522-A1 | Polyetherester copolymers as drug delivery matricess | IsoTis N.V. (NL) | 2002-10-09 | — | — | EP | disclosed |
| EP-1247537-A1 | Coating for medical devices | Isotis B.V. (NL) | 2002-10-09 | — | — | EP | disclosed |
| US-20020128378-A1 | Molding of a polymer | ISOTIS N.V. (NL) | 2002-09-12 | — | — | US | disclosed |
| EP-1200138-A1 | MOLDING OF A POLYMER | IsoTis N.V. (NL) | 2002-05-02 | — | — | EP | disclosed |
| EP-1090928-A1 | Polymers loaded with bioactive agents | IsoTis N.V. (NL) | 2001-04-11 | — | — | EP | disclosed |
| WO-2001010478-A1 | MOLDING OF A POLYMER | ISOTIS N.V. (NL) | 2001-02-15 | — | — | WO | disclosed |
| EP-0830859-A2 | Polyetheresters copolymers as drug delivery matrices | Osteotech, Inc. (US) | 1998-03-25 | — | — | EP | disclosed |