Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148025 | 0.92 | GPR84 (0.53) | GPR84FFAR1HSPD1BLMHSPE1 | |
| SCHEMBL18322324 | 0.92 | GPR84 (0.53) | GPR84FFAR1HSPD1BLMHSPE1 | |
| SCHEMBL325989 | 0.92 | GPR84 (0.53) | GPR84FFAR1HSPD1BLMHSPE1 | |
| SCHEMBL9297272 | 0.92 | GPR84 (0.53) | GPR84FFAR1HSPD1BLMHSPE1 | |
| SCHEMBL6686309 | 0.90 | GPR84 (0.52) | GPR84FFAR1HSPD1BLMHSPE1 | |
| Ammonia Solution, Strong SCHEMBL10519337 | 0.90 | GPR84 (0.52) | GPR84FFAR1HSPD1BLMHSPE1 | |
| Ethylene Glycol SCHEMBL26926887 | 0.87 | GPR84 (0.48) | GPR84FFAR1HSPD1BLMHSPE1 | |
| SCHEMBL2065137 | 0.86 | CHRM1 (0.42) | GPR84FFAR1HSPD1BLMHSPE1 | |
| Glycerin SCHEMBL158648 | 0.85 | GPR84 (0.49) | GPR84FFAR1HSPD1BLMHSPE1 | |
| SCHEMBL28356481 | 0.85 | GPR84 (0.47) | GPR84FFAR1HSPD1BLMHSPE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277311-A1 | LIPOXIN COMPOUNDS AND THEIR USE IN TREATING CELL PROLIFERATIVE DISORDERS | THE BRIGHAM AND WOMEN'S HOSPITAL , INC. | 2012-11-01 | — | — | US | disclosed |
| US-7825271-B2 | Lipoxin compounds and their use in treating cell proliferative disorders | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-7741369-B2 | Lipoxin compounds and their use in treating cell proliferative disorders | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2010-06-22 | — | — | US | disclosed |
| US-20090270498-A1 | Lipoxin Compounds and Their use in Treating Cell Proliferative Disorders | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2009-10-29 | — | — | US | disclosed |
| US-20090258945-A1 | Lipoxin Compounds and Their Use in Treating Cell Proliferative Disorders | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2009-10-15 | — | — | US | disclosed |
| EP-2107050-A1 | Lipoxin compounds | The Brigham and Women's Hospital, Inc. (US) | 2009-10-07 | — | — | EP | disclosed |
| EP-2058293-A1 | Lipoxin compounds and their use in treating cell proliferative disorders | The Brigham & Women's Hospital, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| EP-0703897-B1 | LIPOXIN COMPOUNDS WITH PROLONGED HALF-LIFE | BRIGHAM & WOMENS HOSPITAL (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1201639-B1 | Lipoxin compounds and their use in treating cell proliferative disorders | BRIGHAM & WOMENS HOSPITAL (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7294728-B2 | Lipoxin compounds and their use in treating cell proliferative disorders | SERHAN CHARLES N | 2007-11-13 | — | — | US | disclosed |
| US-20020010351-A1 | Lipoxin compounds and their use in treating cell proliferative disorders | SERHAN CHARLES N (US) | 2002-01-24 | — | — | US | disclosed |
| US-6316648-B1 | PURIFIED 5,6,15-TRIHYDROXY-7,9,13-TRANS-11-CIS-EICOSATETRAENOIC ACID; ANTICARCINOGENIC AND ANTIPROLIFERATIVE AGENTS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2001-11-13 | — | — | US | disclosed |
| US-20010031882-A1 | Lipoxin compounds and their use in treating cell proliferative disorders | SERHAN CHARLES N (US) | 2001-10-18 | — | — | US | disclosed |
| US-6048897-A | ALSO ANTICARCINOGENIC OR ANTITUMOR AGENTS | BRIGHAM AND WOMEN'S HOSPITAL (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0927150-A1 | LIPOXIN COMPOUNDS AND THEIR USE IN TREATING CELL PROLIFERATIVE DISORDERS | BRIGHAM & WOMEN'S HOSPITAL (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998011049-A1 | LIPOXIN COMPOUNDS AND THEIR USE IN TREATING CELL PROLIFERATIVE DISORDERS | BRIGHAM & WOMEN'S HOSPITAL (US) | 1998-03-19 | — | — | WO | disclosed |
| US-5648512-A | Lipoxin compounds | BRIGHAM & WOMENS HOSPITAL (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0703897-A1 | LIPOXIN COMPOUNDS | BRIGHAM & WOMEN'S HOSPITAL (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5441951-A | Lipoxin compounds | BRIGHAM & WOMEN'S HOSPITAL (US) | 1995-08-15 | — | — | US | disclosed |
| WO-1994029262-A1 | LIPOXIN COMPOUNDS | BRIGHAM & WOMEN'S HOSPITAL (US) | 1994-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258945-A1 | Lipoxin Compounds and Their Use in Treating Cell Proliferative Disorders | ALOX15, ALOX12, ALOX15B | CA2 4848/4885MAPK1 2822/4885GPR84 3209/4885 |
| US-20020010351-A1 | Lipoxin compounds and their use in treating cell proliferative disorders | ALOX15, ALOX12, ALOX15B | CA2 4848/4885MAPK1 2822/4885GPR84 3209/4885 |
| US-20090270498-A1 | Lipoxin Compounds and Their use in Treating Cell Proliferative Disorders | ALOX15, ALOX12, ALOX15B | CA2 4848/4885MAPK1 2822/4885GPR84 3209/4885 |
| US-20010031882-A1 | Lipoxin compounds and their use in treating cell proliferative disorders | ALOX15, ALOX12, ALOX15B | CA2 4848/4885MAPK1 2822/4885GPR84 3209/4885 |
| US-20120277311-A1 | LIPOXIN COMPOUNDS AND THEIR USE IN TREATING CELL PROLIFERATIVE DISORDERS | ALOX15, ALOX12, ALOX15B | CA2 4848/4885MAPK1 2822/4885GPR84 3209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.