Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 13/20 | 0.83 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.70 |
| ▸ | P2RX1 | P51575 | 7/20 | 0.70 |
| ▸ | P2RX4 | Q99571 | 7/20 | 0.70 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | IKBKB | O14920 | 1/20 | 0.70 |
| ▸ | CHUK | O15111 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | MYLK | Q15746 | 1/20 | 0.70 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.70 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.65 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.63 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330166 | 0.91 | TMPRSS4 (1.00) | TMPRSS4CHRNA7P2RX1P2RX4P2RX7 | |
| SCHEMBL30100391 | 0.90 | TMPRSS4 (0.79) | TMPRSS4CHRNA7P2RX1P2RX4P2RX7 | |
| SCHEMBL18341401 | 0.90 | TMPRSS4 (0.79) | TMPRSS4CHRNA7P2RX1P2RX4P2RX7 | |
| SCHEMBL330413 | 0.88 | TMPRSS4 (1.00) | TMPRSS4CHRNA7P2RX1P2RX4P2RX7 | |
| SCHEMBL14885961 | 0.87 | TMPRSS4 (0.79) | TMPRSS4CHRNA7P2RX1P2RX4P2RX7 | |
| SCHEMBL330058 | 0.87 | TMPRSS4 (0.67) | TMPRSS4CHRNA7P2RX1P2RX4P2RX7 | |
| SCHEMBL330554 | 0.87 | TMPRSS4 (0.67) | TMPRSS4CHRNA7P2RX1P2RX4P2RX7 | |
| SCHEMBL330394 | 0.87 | TMPRSS4 (0.79) | TMPRSS4CHRNA7P2RX1P2RX4P2RX7 | |
| SCHEMBL330387 | 0.86 | KCNMA1 (0.81) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL5066868 | 0.86 | TMPRSS4 (0.81) | TMPRSS4P2RX1P2RX4P2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221411-A1 | 2-HYDROXYARYLAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING SAME AS ACTIVE INGREDIENT | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2014-08-07 | — | — | US | claimed |
| US-12503425-B2 | Methods of treating or controlling cytotoxic cerebral edema | AEROMICS, INC. (US) | 2025-12-23 | — | — | US | disclosed |
| US-20240360077-A1 | METHODS | AEROMICS, INC. | 2024-10-31 | — | — | US | disclosed |
| US-11873266-B2 | Methods of treating or controlling cytotoxic cerebral edema consequent to an ischemic stroke | AEROMICS, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| US-20220081391-A1 | METHODS | AEROMICS, INC. | 2022-03-17 | — | — | US | disclosed |
| CN-109512805-B | Compounds for the treatment of aquaporin mediated diseases | 埃罗米克斯公司 | 2021-12-31 | — | — | CN | disclosed |
| US-11084778-B2 | Methods of treating cardiac edema, neuromyelitis optica, and hyponatremia | AEROMICS, INC. (US) | 2021-08-10 | — | — | US | disclosed |
| US-20180334424-A1 | METHODS | AEROMICS, INC. | 2018-11-22 | — | — | US | disclosed |
| EP-2846787-B1 | Compounds for use in the treatment of aquaporin-mediated diseases | AEROMICS INC (US) | 2018-08-29 | — | — | EP | disclosed |
| US-9994514-B2 | Methods of treating cerebral edema and spinal cord edema | AEROMICS, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| EP-1510207-A1 | THERAPEUTIC DRUG FOR DIABETES | Institute of Medicinal Molecular Design, Inc. (JP) | 2005-03-02 | — | — | EP | disclosed |
| US-20040259877-A1 | Inhibitors against the production and release of inflammatory cytokines | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2004-12-23 | — | — | US | disclosed |
| CN-1489458-A | Inflammatory cytokine production dissociation inhibitor | ��ʽ����ҽҩ��������о��� | 2004-04-14 | — | — | CN | disclosed |
| EP-1352650-A1 | INHIBITORS AGAINST THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINES | Institute of Medicinal Molecular Design, Inc. (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5656376-A | ANTI-FOULING, CAVITATION RESISTANCE, VIBRATION DAMPING | THE B. F. GOODRICH COMPANY (US) | 1997-08-12 | — | — | US | disclosed |
| US-5582528-A | Composite and fairwater structures for marine vessels | THE B. F. GOODRICH COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| US-5540173-A | Composite and fairwater structures for marine vessels | THE BF GOODRICH COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0710544-A2 | A laminate and a process for forming the same | THE B.F. GOODRICH COMPANY (US) | 1996-05-08 | — | — | EP | disclosed |
| US-5292270-A | Composite and fairwater structures for marine vessels | THE B. F. GOODRICH COMPANY (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0528219-A2 | Composite and fairwater structures for marine vessels | THE B.F. GOODRICH COMPANY (US) | 1993-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180334424-A1 | METHODS | AQP4, AQP1, AQP3 | TMPRSS4 1257/4885CHRNA7 4199/4885P2RX1 2910/4885 |
| US-12503425-B2 | Methods of treating or controlling cytotoxic cerebral edema | AQP4, AQP1, AQP3 | TMPRSS4 1043/4885CHRNA7 4091/4885P2RX1 2714/4885 |
| US-20220081391-A1 | METHODS | AQP4, AQP1, AQP3 | TMPRSS4 1257/4885CHRNA7 4199/4885P2RX1 2910/4885 |
| US-11084778-B2 | Methods of treating cardiac edema, neuromyelitis optica, and hyponatremia | AQP4, AQP1, AQP3 | TMPRSS4 946/4885CHRNA7 4190/4885P2RX1 2805/4885 |
| US-20140221411-A1 | 2-HYDROXYARYLAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING SAME AS ACTIVE INGREDIENT | TMPRSS2, TMPRSS4, PRSS2 | TMPRSS4 2/4885CHRNA7 4662/4885P2RX1 4273/4885 |
| US-11873266-B2 | Methods of treating or controlling cytotoxic cerebral edema consequent to an ischemic stroke | AQP4, AQP1, AQP3 | TMPRSS4 1444/4885CHRNA7 4283/4885P2RX1 3317/4885 |
| US-20040259877-A1 | Inhibitors against the production and release of inflammatory cytokines | NFKBIA, IL1B, IKBKB | TMPRSS4 3292/4885CHRNA7 2622/4885P2RX1 2316/4885 |
| US-20240360077-A1 | METHODS | AQP4, AQP1, AQP3 | TMPRSS4 1415/4885CHRNA7 4105/4885P2RX1 2797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.