Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 8/20 | 0.51 |
| ▸ | CD40 | P25942 | 1/20 | 0.49 |
| ▸ | CD40LG | P29965 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DNASE1L3 | Q13609 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666978 | 0.87 | CYP1A2 (0.52) | CYP1A2ALDH1A1HIF1AMEN1THRB | |
| SCHEMBL105571 | 0.85 | CYP1A2 (0.51) | CYP1A2ALDH1A1HIF1AMEN1THRB | |
| SCHEMBL4280353 | 0.81 | ALDH1A1 (0.54) | CYP1A2ALDH1A1HIF1AMEN1THRB | |
| SCHEMBL3203561 | 0.81 | ALDH1A1 (0.54) | CYP1A2ALDH1A1HIF1AMEN1THRB | |
| SCHEMBL4280346 | 0.80 | ALDH1A1 (0.53) | CYP1A2ALDH1A1HIF1AMEN1THRB | |
| SCHEMBL11759576 | 0.80 | ALDH1A1 (0.53) | CYP1A2ALDH1A1HIF1AMEN1THRB | |
| SCHEMBL1259518 | 0.79 | CYP1A2 (0.74) | CYP1A2ALDH1A1HIF1AMEN1THRB | |
| SCHEMBL3215642 | 0.78 | CYP1A2 (0.62) | CYP1A2ALDH1A1HIF1AMEN1THRB | |
| SCHEMBL517711 | 0.77 | CASP6 (0.54) | CYP1A2ALDH1A1HIF1AMEN1THRB | |
| SCHEMBL2527187 | 0.77 | CYP1A2 (0.60) | CYP1A2ALDH1A1HIF1AMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128457-A | Medical diagnosis | MILES INC. (US) | 1992-07-07 | — | — | US | claimed |
| US-20180311237-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | ZPNE GROUP GMBH (CH) | 2018-11-01 | — | — | US | disclosed |
| US-20150031701-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | ZPNE GROUP GMBH (CH) | 2015-01-29 | — | — | US | disclosed |
| US-20130259930-A1 | Compositions and Methods for Preventing and Treating Mucositis and Weight Loss | CASCADE ESTATE LTD. (MU) | 2013-10-03 | — | — | US | disclosed |
| US-20120196825-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM | SUPPORTIVE THERAPEUTICS AG (CH) | 2012-08-02 | — | — | US | disclosed |
| US-20100092547-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | ZPNE GROUP GMBH (CH) | 2010-04-15 | — | — | US | disclosed |
| EP-2134347-A2 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | Prendergast, Patrick T. (AU) | 2009-12-23 | — | — | EP | disclosed |
| US-20090156546-A1 | Compositions and methods for modulating the immune system | SUPPORTIVE THERAPEUTICS AG (CH) | 2009-06-18 | — | — | US | disclosed |
| EP-2026810-A2 | COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM | Prendergast, Patrick T. (AU) | 2009-02-25 | — | — | EP | disclosed |
| WO-2008110585-A2 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | PRENDERGAST PATRICK T (AU) | 2008-09-18 | — | — | WO | disclosed |
| WO-2007131973-A2 | COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM | PRENDERGAST PATRICK T (AU) | 2007-11-22 | — | — | WO | disclosed |
| US-20040053989-A1 | Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement | PATRICK PRENDERGAST (IE) | 2004-03-18 | — | — | US | disclosed |
| WO-2001009118-A2 | DITHIOLTHIONE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS AND FOR MEMORY ENHANCEMENT | PRENDERGAST PATRICK T (IE) | 2001-02-08 | — | — | WO | disclosed |
| EP-0348826-B1 | Isobenzothiazolone chromogenic thiol indicators and their derivatives | MILES INC (US) | 1994-04-13 | — | — | EP | disclosed |
| US-5187265-A | Medical diagnosis | MILES INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5187105-A | Process for determining thiols using chromogenic benzoisothiazolone derivatives | MILES INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5130433-A | Indicators for detection of thiol | MILES INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5128457-A | Medical diagnosis | MILES INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0348826-A2 | Isobenzothiazolone chromogenic thiol indicators and their derivatives | MILES INC. (US) | 1990-01-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180311237-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | SI, MTPN, MUC1 | CYP1A2 1543/4885ALDH1A1 2388/4885HIF1A 3170/4885 |
| US-20100092547-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | MTAP, TPMT, MUC1 | CYP1A2 2624/4885ALDH1A1 1688/4885HIF1A 3466/4885 |
| US-20150031701-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | SI, MTPN, MUC1 | CYP1A2 1543/4885ALDH1A1 2388/4885HIF1A 3170/4885 |
| US-20040053989-A1 | Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement | PNMT, CHAT, MAPT | CYP1A2 3562/4885ALDH1A1 243/4885HIF1A 3991/4885 |
| US-20130259930-A1 | Compositions and Methods for Preventing and Treating Mucositis and Weight Loss | SI, MTPN, MUC1 | CYP1A2 1543/4885ALDH1A1 2388/4885HIF1A 3170/4885 |
| US-20090156546-A1 | Compositions and methods for modulating the immune system | MRE11, XPA, MPL | CYP1A2 3863/4885ALDH1A1 3955/4885HIF1A 1186/4885 |
| US-20120196825-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM | MRE11, XPA, MPL | CYP1A2 3863/4885ALDH1A1 3955/4885HIF1A 1186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.