Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3301483 | 1.00 | NPC1 (0.40) | NPC1RAB9AALDH1A1HPGDMAPK1 | |
| SCHEMBL3303995 | 0.91 | NPC1 (0.40) | NPC1RAB9AALDH1A1HPGDMAPK1 | |
| SCHEMBL3303985 | 0.91 | NPC1 (0.40) | NPC1RAB9AALDH1A1HPGDMAPK1 | |
| SCHEMBL14028913 | 0.90 | CYP3A4 (0.42) | NPC1RAB9AALDH1A1HPGDMAPK1 | |
| Deferitrin SCHEMBL1272026 | 0.87 | TYR (0.35) | ALDH1A1HPGDMAPTPOLBHTT | |
| Deferitrin SCHEMBL18103545 | 0.87 | TYR (0.35) | ALDH1A1HPGDMAPTPOLBHTT | |
| Deferitrin SCHEMBL663744 | 0.87 | TYR (0.35) | ALDH1A1HPGDMAPTPOLBHTT | |
| SCHEMBL20175902 | 0.86 | CNR1 (0.41) | NPC1ALDH1A1HPGDMAPK1KMT2A | |
| SCHEMBL11963215 | 0.86 | SLC22A12 (0.39) | — | |
| SCHEMBL18189628 | 0.85 | PPARD (0.42) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570104-B2 | Metabolically programmed metal chelators and uses thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2020-02-25 | — | — | US | disclosed |
| EP-3190106-B1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIV FLORIDA (US) | 2019-05-08 | — | — | EP | disclosed |
| US-9994535-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA FOUNDATION, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-20180140581-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2018-05-24 | — | — | US | disclosed |
| US-9730917-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730917-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-08-15 | — | — | US | disclosed |
| US-20170217912-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2017-08-03 | — | — | US | disclosed |
| EP-3190106-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | University of Florida Research Foundation, Inc. (US) | 2017-07-12 | — | — | EP | disclosed |
| US-9567309-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2017-02-14 | — | — | US | disclosed |
| WO-2016176343-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2016-11-03 | — | — | WO | disclosed |
| US-20100137346-A1 | DESFERRITHIOCIN ANALOGUE ACTINIDE DECORPORATION AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100137346-A1 | DESFERRITHIOCIN ANALOGUE ACTINIDE DECORPORATION AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| EP-2137170-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-12-30 | — | — | EP | disclosed |
| EP-2101764-A2 | DESFERRITHIOCIN ANALOGUE ACTINIDE DECORPORATION AGENTS | UNIVERSITY OF FLORIDA (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008130395-A2 | DESFERRITHIOCIN ANALOGUE ACTINIDE DECORPORATION AGENTS | UNIVERSITY OF FLORIDA (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008115433-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA (US) | 2008-09-25 | — | — | WO | disclosed |
| US-20080214630-A1 | Oral bioavailability; minimal toxicity; low concentration in the kidneys after administration; reduce oxidative stress; (S)-4,5-Dihydro-2-[2-hydroxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid; condition responsive to chelation or sequestration of a trivalent metal | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2008-09-04 | — | — | US | disclosed |
| US-20080214630-A1 | Oral bioavailability; minimal toxicity; low concentration in the kidneys after administration; reduce oxidative stress; (S)-4,5-Dihydro-2-[2-hydroxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid; condition responsive to chelation or sequestration of a trivalent metal | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570104-B2 | Metabolically programmed metal chelators and uses thereof | FECH, SLC19A1, SLC40A1 | NPC1 382/4885RAB9A 954/4885ALDH1A1 181/4885 |
| US-20180140581-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | FECH, SLC19A1, SLC40A1 | NPC1 382/4885RAB9A 954/4885ALDH1A1 181/4885 |
| US-20170217912-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | SLC40A1, DNAJC10, FTH1 | NPC1 449/4885RAB9A 1797/4885ALDH1A1 2588/4885 |
| US-20080214630-A1 | Oral bioavailability; minimal toxicity; low concentration in the kidneys after administration; reduce oxidative stress; (S)-4,5-Dihydro-2-[2-hydroxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid; condition responsive to chelation or sequestration of a trivalent metal | SLC7A1, SLC19A1, SLC10A6 | NPC1 1268/4885RAB9A 1698/4885ALDH1A1 364/4885 |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | SLC40A1, HAMP, FTH1 | NPC1 1819/4885RAB9A 3667/4885ALDH1A1 4214/4885 |
| US-20100137346-A1 | DESFERRITHIOCIN ANALOGUE ACTINIDE DECORPORATION AGENTS | TFRC, SLC40A1, FIBP | NPC1 613/4885RAB9A 691/4885ALDH1A1 3340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.