Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15539513 | 1.00 | MEN1 (1.00) | MEN1KMT2AHPGDHSD17B10NR1I2 | |
| SCHEMBL15540388 | 1.00 | MEN1 (1.00) | MEN1KMT2AHPGDHSD17B10NR1I2 | |
| Hydrochloric Acid SCHEMBL29006873 | 0.85 | MEN1 (0.74) | MEN1KMT2AHPGDHSD17B10NR1I2 | |
| SCHEMBL10219787 | 0.82 | KMT2A (0.68) | MEN1KMT2AHPGDHSD17B10NR1I2 | |
| SCHEMBL5865198 | 0.81 | MEN1 (0.69) | MEN1KMT2AHPGDHSD17B10HTT | |
| SCHEMBL1027011 | 0.81 | HPGD (0.68) | MEN1KMT2AHPGDHSD17B10HTT | |
| SCHEMBL2146965 | 0.81 | MEN1 (0.68) | MEN1KMT2AHPGDHSD17B10HTT | |
| SCHEMBL4233005 | 0.79 | MEN1 (0.66) | MEN1KMT2AHPGDHSD17B10HTT | |
| Hydrochloric Acid SCHEMBL9787788 | 0.79 | HPGD (0.66) | MEN1KMT2AHPGDHSD17B10HTT | |
| Bromide SCHEMBL10432863 | 0.79 | HPGD (0.66) | MEN1KMT2AHPGDHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104428293-B | Adjust the benzimidazole of TNF α | UCB生物制药私人有限公司 | 2018-06-08 | — | — | CN | disclosed |
| EP-2858983-B1 | TNF-ALPHA MODULATING BENZIMIDAZOLES | UCB BIOPHARMA SPRL (BE) | 2018-04-18 | — | — | EP | disclosed |
| US-9550737-B2 | TNF -α modulating benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2017-01-24 | — | — | US | disclosed |
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2015-06-04 | — | — | US | disclosed |
| EP-2858983-A1 | TNF -ALPHA MODULATING BENZIMIDAZOLES | UCB Biopharma SPRL (BE) | 2015-04-15 | — | — | EP | disclosed |
| EP-1401838-B1 | NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-26 | — | — | EP | disclosed |
| WO-2013186229-A1 | TNF -ALPHA MODULATING BENZIMIDAZOLES | UCB PHARMA S.A. (BE) | 2013-12-19 | — | — | WO | disclosed |
| US-8216800-B2 | Substrates for detecting peptidase activity and methods using the substrates | BIOMERIEUX (FR) | 2012-07-10 | — | — | US | disclosed |
| US-7732437-B2 | Use of anti-histaminics for acute reduction of elevated intracranial pressure | JANSSEN PHARMACEUTICA, NV. (BE) | 2010-06-08 | — | — | US | disclosed |
| US-20100099128-A1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX (FR) | 2010-04-22 | — | — | US | disclosed |
| US-7476662-B2 | Substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-13 | — | — | US | disclosed |
| EP-1451196-B1 | The use of substituted tetracyclic imidazole derivatives as anti-histaminics | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-15 | — | — | EP | disclosed |
| US-20050070525-A1 | Use of anti-histaminics for acute reduction of elevated intracranial pressure | JANSSEN-CILAG GMBH (DE) | 2005-03-31 | — | — | US | disclosed |
| EP-1451196-A1 | THE USE OF ANTI-HISTAMINICS FOR ACUTE REDUCTION OF ELEVATED INTRACRANIAL PRESSURE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-09-01 | — | — | EP | disclosed |
| US-20040167138-A1 | Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharamaceutical compositions comprising them and their use as a medicine | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-08-26 | — | — | US | disclosed |
| EP-1401838-A2 | NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003044023-A1 | THE USE OF ANTI-HISTAMINICS FOR ACUTE REDUCTION OF ELEVATED INTRACRANIAL PRESSURE | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-05-30 | — | — | WO | disclosed |
| WO-2002100862-A2 | NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | TNF, TNFRSF1A, NFKBIA | MEN1 3836/4885KMT2A 3732/4885HPGD 1362/4885 |
| US-20050070525-A1 | Use of anti-histaminics for acute reduction of elevated intracranial pressure | HRH2, HRH3, HRH4 | MEN1 1022/4885KMT2A 340/4885HPGD 90/4885 |
| US-20100099128-A1 | NOVEL PEPTIDASE SUBSTRATES | XPNPEP1, DPEP1, DDAH1 | MEN1 899/4885KMT2A 4000/4885HPGD 1975/4885 |
| US-20040167138-A1 | Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharamaceutical compositions comprising them and their use as a medicine | AIFM1, PTGIS, ATP6V1B2 | MEN1 1841/4885KMT2A 3372/4885HPGD 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.