SCHEMBL3308973

SCHEMBL3308973

COC(=O)c1cc(Cl)cc(C)c1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.47
ABL1 P00519 1/20 0.46
SERPINH1 P50454 1/20 0.45
SLC6A4 P31645 1/20 0.44
SLC6A3 Q01959 1/20 0.44
BCL2 P10415 1/20 0.43
USP2 O75604 1/20 0.42
ALDH1A1 P00352 1/20 0.42
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA7 P43166 2/20 0.42
CA9 Q16790 2/20 0.42
CA14 Q9ULX7 2/20 0.42
PDK2 Q15119 2/20 0.42
PDK4 Q16654 1/20 0.42
KDM4E B2RXH2 1/20 0.41
LMNA P02545 1/20 0.41
POLB P06746 1/20 0.41
GAA P10253 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30810238 1.00 BCL2L1 (0.47) BCL2L1ABL1SERPINH1SLC6A4SLC6A3
SCHEMBL423691 0.83 AKR1C4 (0.60) ABL1SERPINH1SLC6A4SLC6A3ALDH1A1
SCHEMBL855750 0.83 LMNA (0.52) ABL1SERPINH1SLC6A4SLC6A3ALDH1A1
SCHEMBL2657833 0.83 ABL1 (0.47) ABL1SERPINH1SLC6A4SLC6A3USP2
SCHEMBL15766375 0.81 CYP3A4 (0.49) ABL1SERPINH1SLC6A4SLC6A3USP2
SCHEMBL12478545 0.81 ABL1 (0.46) ABL1SERPINH1SLC6A4SLC6A3CA12
SCHEMBL23796581 0.81 CYP3A4 (0.56) BCL2L1ABL1CA12CA1CA2
SCHEMBL13779473 0.81 CA1 (0.50) CA12CA1CA2CA7CA9
SCHEMBL8395371 0.81 GAA (0.45) ALDH1A1CA12CA1CA2CA7
SCHEMBL19612124 0.80 ALDH1A1 (0.47) ABL1SERPINH1SLC6A4SLC6A3USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054766-A2 MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER MITO BIOPHARMA, LLC (US) 2024-03-14 WO disclosed
US-8569535-B2 Substituted benzoylamino-indan-2-carboxylic acids and related compounds SANOFI (FR) 2013-10-29 US disclosed
US-8569535-B2 Substituted benzoylamino-indan-2-carboxylic acids and related compounds SANOFI (FR) 2013-10-29 US disclosed
US-8569535-B2 Substituted benzoylamino-indan-2-carboxylic acids and related compounds SANOFI (FR) 2013-10-29 US disclosed
US-20100113462-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS SANOFI-AVENTIS (FR) 2010-05-06 US disclosed
US-20100113462-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS SANOFI-AVENTIS (FR) 2010-05-06 US disclosed
US-20100113462-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS SANOFI-AVENTIS (FR) 2010-05-06 US disclosed
CN-101679346-A substituted benzoylamino-indan-2-carboxylic acids and related compounds SANOFI AVENTIS 2010-03-24 CN disclosed
EP-2155711-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS Sanofi-Aventis (FR) 2010-02-24 EP disclosed
WO-2008151211-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS SANOFI-AVENTIS (FR) 2008-12-11 WO disclosed
WO-2008151211-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS SANOFI-AVENTIS (FR) 2008-12-11 WO disclosed
EP-0249708-B1 2-PHENOXYPYRIMIDINE DERIVATIVE AND HERBICIDAL COMPOSITIONS KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1992-03-11 EP disclosed
US-4985066-A 2-phenoxypyrimidine derivative and herbicidal composition KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1991-01-15 US disclosed
US-4900352-A 2-Phenoxypyimidine derivative and herbicidal composition KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1990-02-13 US disclosed
EP-0249708-A1 2-Phenoxypyrimidine derivative and herbicidal compositions KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1987-12-23 EP disclosed
US-4060637-A 5-BROMO-N-(N,N'-DIALKYLAMINOALKYL)-O-CRESOTAMIDES PIERRE FABRE SA (FR) 1977-11-29 US disclosed
US-3958002-A ADMINISTERING PIERRE FABRE S.A. (FR) 1976-05-18 US disclosed
US-3941878-A ASPIRIN, A CRESOTAMIDE PIERRE FABRE S.A. (FR) 1976-03-02 US disclosed
US-3940490-A N-ALKYL-5-BROMO-ORTHO-CRESOTAMIDES, ANTICONVULSANT PIERRE FABRE S.A. (FR) 1976-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100113462-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS CXCR5, CXCR1, CCR5 BCL2L1 1268/4885ABL1 2981/4885SERPINH1 3822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.