Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | TLR4 | O00206 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5346726 | 0.88 | CYP1A2 (0.41) | CYP1A2HIF1AALDH1A1BRD4KMT2A | |
| SCHEMBL3974812 | 0.88 | CYP1A2 (0.43) | CYP1A2HIF1ACHRM2CHRM4CHRM3 | |
| SCHEMBL12798508 | 0.81 | CYP1A2 (0.39) | CYP1A2HIF1ACHRM2CHRM4CHRM3 | |
| SCHEMBL5659584 | 0.80 | TLR4 (0.50) | ALDH1A1KMT2ASMN1; SMN2HTTHSD17B10 | |
| SCHEMBL11782843 | 0.79 | CYP1A2 (0.38) | CYP1A2HIF1ACHRM2CHRM4CHRM3 | |
| SCHEMBL13882832 | 0.79 | CYP1A2 (0.46) | CYP1A2HIF1AALDH1A1BRD4KMT2A | |
| SCHEMBL31648667 | 0.78 | CA1 (0.37) | CA1CA2CA4KMT2AAPOBEC3A | |
| SCHEMBL5896856 | 0.77 | TLR4 (0.47) | ALDH1A1KMT2ASMN1; SMN2HTTHSD17B10 | |
| SCHEMBL3362070 | 0.76 | CYP1A2 (0.38) | CYP1A2HIF1ACHRM2CHRM4CHRM3 | |
| SCHEMBL30052789 | 0.74 | BRD4 (0.36) | CYP1A2HIF1ACHRM2CHRM4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4574821-B1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS INC (US) | 2026-02-04 | — | — | EP | disclosed |
| EP-3893889-B1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS INC (US) | 2026-01-28 | — | — | EP | disclosed |
| US-20260001867-A1 | THR BETA RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2026-01-01 | — | — | US | disclosed |
| US-12459926-B2 | THRβ receptor agonist compound and preparation method and use thereof | Terns, Inc. (US) | 2025-11-04 | — | — | US | disclosed |
| US-12365669-B2 | THRβ receptor agonist compound and preparation method and use thereof | Terns, Inc. (US) | 2025-07-22 | — | — | US | disclosed |
| EP-4574821-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | Terns, Inc. (US) | 2025-06-25 | — | — | EP | disclosed |
| US-12338232-B2 | THRβ receptor agonist compound and preparation method and use thereof | Terns, Inc. (US) | 2025-06-24 | — | — | US | disclosed |
| US-20250179053-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2025-06-05 | — | — | US | disclosed |
| US-20250179054-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2025-06-05 | — | — | US | disclosed |
| EP-4529954-A2 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | Terns, Inc. (US) | 2025-04-02 | — | — | EP | disclosed |
| US-20230278988-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2023-09-07 | — | — | US | disclosed |
| CN-116444498-A | THR beta receptor agonist compound, preparation method and application thereof | 拓臻股份有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-113194958-B | THR beta receptor agonist compound, preparation method and application thereof | 拓臻股份有限公司 | 2023-05-23 | — | — | CN | disclosed |
| US-11084802-B2 | THRβ receptor agonist compound and preparation method and use thereof | Terns, Inc. (US) | 2021-08-10 | — | — | US | disclosed |
| CN-113194958-A | THR beta receptor agonist compound and preparation method and application thereof | 拓臻股份有限公司 | 2021-07-30 | — | — | CN | disclosed |
| US-11034676-B2 | THRB receptor agonist compound and preparation method and use thereof | Terns, Inc. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200399249-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2020-12-24 | — | — | US | disclosed |
| CN-111320609-A | THR β receptor agonist compound and preparation method and application thereof | 拓臻股份有限公司 | 2020-06-23 | — | — | CN | disclosed |
| US-20200190064-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2020-06-18 | — | — | US | disclosed |
| US-20100113415-A1 | EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER | MERCK SHARP & DOHME CORP | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250179054-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | CYP1A2 2056/4885HIF1A 2007/4885CHRM2 731/4885 |
| US-20260001867-A1 | THR BETA RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, ADRB1 | CYP1A2 1221/4885HIF1A 1204/4885CHRM2 146/4885 |
| US-20250179053-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | CYP1A2 2056/4885HIF1A 2007/4885CHRM2 731/4885 |
| US-20200190064-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | CYP1A2 2056/4885HIF1A 2007/4885CHRM2 731/4885 |
| US-20230278988-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | CYP1A2 2056/4885HIF1A 2007/4885CHRM2 731/4885 |
| US-12459926-B2 | THRβ receptor agonist compound and preparation method and use thereof | THRB, THRA, TRHR | CYP1A2 1945/4885HIF1A 1810/4885CHRM2 590/4885 |
| US-12365669-B2 | THRβ receptor agonist compound and preparation method and use thereof | THRB, THRA, TRHR | CYP1A2 1945/4885HIF1A 1810/4885CHRM2 590/4885 |
| US-11034676-B2 | THRB receptor agonist compound and preparation method and use thereof | THRB, THRA, TRHR | CYP1A2 2056/4885HIF1A 2007/4885CHRM2 731/4885 |
| US-11084802-B2 | THRβ receptor agonist compound and preparation method and use thereof | THRB, THRA, TRHR | CYP1A2 1945/4885HIF1A 1810/4885CHRM2 590/4885 |
| US-12338232-B2 | THRβ receptor agonist compound and preparation method and use thereof | THRB, THRA, TRHR | CYP1A2 1945/4885HIF1A 1810/4885CHRM2 590/4885 |
| US-20200399249-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | CYP1A2 2056/4885HIF1A 2007/4885CHRM2 731/4885 |
| US-20100113415-A1 | EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER | EPHA4, EPHA1, ERBB4 | CYP1A2 1809/4885HIF1A 2368/4885CHRM2 3030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.