SCHEMBL3311657

SCHEMBL3311657

Clc1ccccc1CN1CCOCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP2A13 Q16696 9/20 1.00
SIGMAR1 Q99720 1/20 0.66
KDM4E B2RXH2 3/20 0.65
ALDH1A1 P00352 3/20 0.65
HTT P42858 1/20 0.65
PLA2G1B P04054 1/20 0.62
RAB9A P51151 1/20 0.62
ATG4B Q9Y4P1 1/20 0.62
GAA P10253 1/20 0.61
MAPT P10636 1/20 0.61
CXCR4 P61073 1/20 0.58
MGLL Q99685 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11360607 0.86 SIGMAR1 (0.85) CYP2A13SIGMAR1KDM4EALDH1A1HTT
SCHEMBL11193326 0.86 CYP2A13 (0.75) CYP2A13KDM4EALDH1A1HTTGAA
SCHEMBL4105461 0.86 CYP2A13 (1.00) CYP2A13SIGMAR1KDM4EALDH1A1HTT
SCHEMBL18190383 0.83 CYP2A13 (0.71) CYP2A13SIGMAR1KDM4EALDH1A1HTT
SCHEMBL23851311 0.82 SIGMAR1 (0.72) CYP2A13SIGMAR1KDM4EALDH1A1HTT
SCHEMBL9417737 0.82 SIGMAR1 (0.72) CYP2A13SIGMAR1KDM4EALDH1A1HTT
SCHEMBL4105446 0.82 KCNH2 (0.74) CYP2A13SIGMAR1MGLL
SCHEMBL3738488 0.81 CYP2A13 (0.69) CYP2A13KDM4EALDH1A1HTTGAA
SCHEMBL3129648 0.81 CYP2A13 (0.68) CYP2A13SIGMAR1KDM4EALDH1A1HTT
SCHEMBL3210628 0.81 ALDH1A1 (0.73) CYP2A13SIGMAR1KDM4EALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8598165-B2 Morpholines as selective inhibitors of cytochrome P450 2A13 UNIVERSITY OF KANSAS (US) 2013-12-03 US claimed
US-20090137592-A1 MORPHOLINES AS SELECTIVE INHIBITORS OF CYTOCHROME P450 2A13 NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2009-05-28 US claimed
CN-105814012-B The preparation method of two alpha substituted benzylamines, the particularly dialkyl benzylamine of halo of halo 拜耳作物科学股份公司 2018-01-26 CN disclosed
EP-3080070-B1 METHOD FOR THE PREPARATION OF HALOGENATED DI-SUBSTITUTED BENZYLAMINES, IN PARTICULAR HALOGENETED DIALKYLBENZYLAMINES BAYER CROPSCIENCE AG (DE) 2017-11-01 EP disclosed
US-9670135-B2 Preparation of halogenated di-substituted benzylamines, particularly halogenated dialkylbenzylamines BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-06-06 US disclosed
US-20160304435-A1 PREPARATION OF HALOGENATED DI-SUBSTITUTED BENZYLAMINES, PARTICULARLY HALOGENATED DIALKYLBENZYLAMINES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-10-20 US disclosed
EP-3080070-A1 METHOD FOR THE PREPARATION OF HALOGENATED DI-SUBSTITUTED BENZYLAMINES, IN PARTICULAR HALOGENATED DIALKYLBENZYLAMINES Bayer CropScience Aktiengesellschaft (DE) 2016-10-19 EP disclosed
CN-105814012-A Method for the preparation of halogenated di-substituted benzylamines, in particular halogenated dialkylbenzylamines 拜耳作物科学股份公司 2016-07-27 CN disclosed
WO-2015086490-A1 METHOD FOR THE PREPARATION OF HALOGENATED DI-SUBSTITUTED BENZYLAMINES, IN PARTICULAR HALOGENATED DIALKYLBENZYLAMINES BAYER CROPSCIENCE AG (DE) 2015-06-18 WO disclosed
US-8962624-B2 Morpholines as selective inhibitors of cytochrome P450 2A13 UNIVERSITY OF KANSAS (US) 2015-02-24 US disclosed
US-8962624-B2 Morpholines as selective inhibitors of cytochrome P450 2A13 UNIVERSITY OF KANSAS (US) 2015-02-24 US disclosed
US-20100113778-A1 PROCESS FOR PREPARING O-CHLOROMETHYLPHENYLGLYOXYLIC ESTERS, IMPROVED PROCESS FOR PREPARING (E)-2-(2-CHLOROMETHYLPHENYL)-2-ALKOXIMINOACETIC ESTERS, AND NOVEL INTERMEDIATES FOR THEIR PREPARATION DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2010-05-06 US disclosed
EP-2134673-A1 IMPROVED PROCESS FOR PREPARING O-CHLOROMETHYLPHENYLGLYOXYLIC ESTERS, IMPROVED PROCESS FOR PREPARING (E)-2-(2-CHLOROMETHYLPHENYL)-2-ALKOXIMINOACETIC ESTERS, AND NOVEL INTERMEDIATES FOR THEIR PREPARATION DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) 2009-12-23 EP disclosed
WO-2009070579-A2 MORPHOLINES AS SELECTIVE INHIBITORS OF CYTOCHROME P450 2A13 UNIVERSITY OF KANSAS (US) 2009-06-04 WO disclosed
US-20090137592-A1 MORPHOLINES AS SELECTIVE INHIBITORS OF CYTOCHROME P450 2A13 NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2009-05-28 US disclosed
US-20090137592-A1 MORPHOLINES AS SELECTIVE INHIBITORS OF CYTOCHROME P450 2A13 NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2009-05-28 US disclosed
US-20090137592-A1 MORPHOLINES AS SELECTIVE INHIBITORS OF CYTOCHROME P450 2A13 NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2009-05-28 US disclosed
WO-2008125592-A1 IMPROVED PROCESS FOR PREPARING O-CHLOROMETHYLPHENYLGLYOXYLIC ESTERS, IMPROVED PROCESS FOR PREPARING (E)-2-(2-CHLOROMETHYLPHENYL)-2-ALKOXIMINOACETIC ESTERS, AND NOVEL INTERMEDIATES FOR THEIR PREPARATION DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2008-10-23 WO disclosed
WO-2008125592-A1 IMPROVED PROCESS FOR PREPARING O-CHLOROMETHYLPHENYLGLYOXYLIC ESTERS, IMPROVED PROCESS FOR PREPARING (E)-2-(2-CHLOROMETHYLPHENYL)-2-ALKOXIMINOACETIC ESTERS, AND NOVEL INTERMEDIATES FOR THEIR PREPARATION DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2008-10-23 WO disclosed
WO-2005095343-A1 DPP-IV INHIBITORS SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) 2005-10-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100113778-A1 PROCESS FOR PREPARING O-CHLOROMETHYLPHENYLGLYOXYLIC ESTERS, IMPROVED PROCESS FOR PREPARING (E)-2-(2-CHLOROMETHYLPHENYL)-2-ALKOXIMINOACETIC ESTERS, AND NOVEL INTERMEDIATES FOR THEIR PREPARATION CYP4F12, GRHPR, CYP4F2 CYP2A13 113/4885SIGMAR1 3473/4885KDM4E 196/4885
US-20090137592-A1 MORPHOLINES AS SELECTIVE INHIBITORS OF CYTOCHROME P450 2A13 CYP1A2, CYP2D6, CYP1A1 CYP2A13 6/4885SIGMAR1 610/4885KDM4E 2221/4885
US-20160304435-A1 PREPARATION OF HALOGENATED DI-SUBSTITUTED BENZYLAMINES, PARTICULARLY HALOGENATED DIALKYLBENZYLAMINES DEK, DRD4, DCK CYP2A13 1398/4885SIGMAR1 1233/4885KDM4E 949/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.