Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HMGCR | P04035 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13334734 | 0.83 | GAA (0.40) | POLBGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8597221 | 0.81 | GAA (0.39) | POLBGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29705770 | 0.81 | GAA (0.42) | POLBGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5003857 | 0.81 | GAA (0.42) | POLBGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14445604 | 0.80 | CYP3A4 (0.47) | GAACYP3A4TSHR | |
| SCHEMBL11345116 | 0.79 | GAA (0.41) | POLBGAACYP3A4CYP2C9CYP2C19 | |
| Potassium Ion SCHEMBL3310678 | 0.79 | GAA (0.38) | POLBGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8598579 | 0.79 | ALDH1A1 (0.45) | POLBGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14561060 | 0.79 | POLB (0.41) | POLBGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11203250 | 0.79 | POLB (0.41) | POLBGAACYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170189562-A1 | Metal Complexes with Bisphosphonate or Pyrophosphate Useful as Imaging Agents | UNIV DUKE (US) | 2017-07-06 | — | — | US | disclosed |
| US-20170189562-A1 | Metal Complexes with Bisphosphonate or Pyrophosphate Useful as Imaging Agents | UNIV DUKE (US) | 2017-07-06 | — | — | US | disclosed |
| WO-2016172552-A1 | METAL COMPLEXES WITH BISPHOSPHONATE OR PYROPHOSPHATE USEFUL AS IMAGING AGENTS | LADERX LLC (US) | 2016-10-27 | — | — | WO | disclosed |
| US-8946144-B2 | Phosphonated glycopeptide and lipoglycopeptide antibiotics and uses thereof for the prevention and treatment of bone and joint infections | THE MEDICINES COMPANY (US) | 2015-02-03 | — | — | US | disclosed |
| US-20100113333-A1 | PHOSPHONATED GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS, INC. (CA) | 2010-05-06 | — | — | US | disclosed |
| EP-2097440-A1 | PHOSPHONATED GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | Targanta Therapeutics Inc. (CA) | 2009-09-09 | — | — | EP | disclosed |
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | TARGANTA THERAPEUTICA INC. (CA) | 2008-11-20 | — | — | US | disclosed |
| WO-2008077241-A1 | PHOSPHONATED GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS, INC. (CA) | 2008-07-03 | — | — | WO | disclosed |
| EP-1881974-A2 | PHOSPHONATED FLUOROQUINOLONES, ANTIBACTERIAL ANALOGS THEREOF, AND METHODS FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | Targanta Therapeutics Inc. (CA) | 2008-01-30 | — | — | EP | disclosed |
| WO-2007138381-A2 | PHOSPHONATED OXAZOLIDINONES AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS INC. (CA) | 2007-12-06 | — | — | WO | disclosed |
| EP-0831869-B1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-0831869-A4 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 1999-04-21 | — | — | EP | disclosed |
| US-5880111-A | CHEMOTHERAPWUTIC AGENTS; TREATING PERIODONTAL DISEASE AND URINARY TRACT INFECTIONS | FARCASIU DAN (US) | 1999-03-09 | — | — | US | disclosed |
| EP-0831869-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | Elizanor Biopharmaceuticals, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| US-5728650-A | Herbicidal aza bisphosphonic acids and compositions containing the same | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |
| EP-0820230-A1 | HERBICIDAL AZA BISPHOSPHONIC ACIDS AND COMPOSITIONS CONTAINING THE SAME | ZENECA LIMITED (GB) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996040190-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996031124-A1 | HERBICIDAL AZA BISPHOSPHONIC ACIDS AND COMPOSITIONS CONTAINING THE SAME | ZENECA LIMITED (GB) | 1996-10-10 | — | — | WO | disclosed |
| US-5391776-A | A bisphosphonate gonanes; selective absorbed by bone; therapy agent for osteoporosis | MITSUBISHI KASEI CORPORATION (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0555845-A2 | Steroid derivatives | MITSUBISHI KASEI CORPORATION (JP) | 1993-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113333-A1 | PHOSPHONATED GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | PGLS, BPGM, PAG1 | POLB 2437/4885GAA 673/4885CYP3A4 4566/4885 |
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | BPGM, PSPH, PGLS | POLB 237/4885GAA 1879/4885CYP3A4 2952/4885 |
| US-20170189562-A1 | Metal Complexes with Bisphosphonate or Pyrophosphate Useful as Imaging Agents | PPIP5K2, MPI, PPA1 | POLB 1902/4885GAA 1873/4885CYP3A4 4681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.