Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2304880 | 0.88 | KCNQ3 (0.68) | KCNQ3KCNQ2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3309149 | 0.86 | LMNA (0.58) | KCNQ3KCNQ2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3312207 | 0.85 | KCNQ3 (0.63) | KCNQ3KCNQ2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3313663 | 0.84 | LMNA (0.58) | KCNQ3KCNQ2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3309585 | 0.82 | ROCK2 (0.53) | KCNQ3KCNQ2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL12707696 | 0.79 | P4HTM (0.67) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3312208 | 0.78 | MEN1 (0.51) | KCNQ3KCNQ2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3309577 | 0.76 | MEN1 (0.45) | KCNQ3KCNQ2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6606130 | 0.76 | MCHR1 (0.62) | KCNQ3KCNQ2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3934629 | 0.76 | LMNA (0.77) | ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, MOGAT2 | KCNQ3 410/4885KCNQ2 300/4885SMN1; SMN2 4749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.