Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.54 |
| ▸ | F2 known ✓ | P00734 | 1/20 | 0.49 |
| ▸ | BCL2L1 known ✓ | Q07817 | 1/20 | 0.47 |
| ▸ | MCL1 known ✓ | Q07820 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 13/20 | 0.63 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.63 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.63 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.63 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.63 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3016749 | 0.89 | PARP10 (0.79) | PARP10PARP15PARP14PARP4ALDH1A1 | |
| SCHEMBL3314861 | 0.81 | SOS1 (0.55) | PARP10ALDH1A1KMT2AMAOBSCN9A | |
| Fumaric Acid SCHEMBL3023454 | 0.80 | PARP10 (0.63) | PARP10PARP15PARP14PARP4ALDH1A1 | |
| SCHEMBL3137816 | 0.80 | PARP10 (1.00) | PARP10PARP15PARP14PARP4ALDH1A1 | |
| SCHEMBL3701690 | 0.80 | OPRM1 (0.63) | PARP10PARP15PARP14PARP4ALDH1A1 | |
| SCHEMBL1448270 | 0.79 | PGR (0.63) | PARP10PARP15PARP14PARP4ALDH1A1 | |
| SCHEMBL703171 | 0.79 | BCL2L1 (0.59) | SCN9ASOS1BCL2L1MCL1 | |
| SCHEMBL12441973 | 0.78 | CES2 (0.62) | PARP10PARP15PARP14PARP4ALDH1A1 | |
| SCHEMBL52708 | 0.78 | CES2 (0.62) | PARP10PARP15PARP14PARP4ALDH1A1 | |
| SCHEMBL6453037 | 0.75 | PARP10 (0.61) | PARP10PARP15PARP14PARP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105651-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R&D) LIMITED (GB) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105651-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | CNR1, OPRL1, CHRNA10 | MAOB 594/4885F2 3487/4885BCL2L1 2602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.