SCHEMBL331750

SCHEMBL331750

C=C(C)C(=O)OCC(O)COC(CC)[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.41
THRB P10828 1/20 0.33
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1284120 0.89 TSHR (0.41) TSHRTHRBALDH1A1
SCHEMBL17727845 0.86 TSHR (0.44) TSHRTHRBALDH1A1
SCHEMBL7996700 0.82 THRB (0.46) TSHRTHRBALDH1A1
SCHEMBL4895740 0.80 TSHR (0.42) TSHRTHRBALDH1A1
SCHEMBL11039923 0.77 TSHR (0.31) TSHR
SCHEMBL10661650 0.77 THRB (0.42) TSHRTHRBALDH1A1
SCHEMBL65879 0.76 TSHR (0.35) TSHRTHRBALDH1A1
SCHEMBL235662 0.76 TSHR (0.47) TSHRTHRBALDH1A1
SCHEMBL13863105 0.76 TSHR (0.47) TSHRTHRBALDH1A1
SCHEMBL94906 0.75 TSHR (0.68) TSHRTHRBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 518 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4657144-A2 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES Alcon Inc. (CH) 2025-12-03 EP claimed
EP-4657145-A2 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES Alcon Inc. (CH) 2025-12-03 EP claimed
US-20250223392-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC (CH) 2025-07-10 US claimed
US-12286501-B2 Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof ALCON INC. (CH) 2025-04-29 US claimed
US-20240254269-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC. (CH) 2024-08-01 US claimed
US-11926689-B2 Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof ALCON INC. (CH) 2024-03-12 US claimed
US-20220380509-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC. (CH) 2022-12-01 US claimed
US-11453736-B2 Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof ALCON INC. (CH) 2022-09-27 US claimed
US-11360241-B2 Biomedical devices containing internal wetting agents JOHNSON & JOHNSON VISION CARE, INC. (US) 2022-06-14 US claimed
EP-3598181-B1 VINYLIC MONOMER AND PREPOLYMER COMPRISING SAME ALCON INC (CH) 2021-06-23 EP claimed
EP-1534759-A1 MACROMER FORMING CATALYSTS Johnson & Johnson Vision Care, Inc. (US) 2005-06-01 EP claimed
WO-2005005517-A2 SILICONE HYDROGELS HAVING CONSISTENT CONCENTRATIONS OF MULTI-FUNCTIONAL POLYSILOXANES JOHNSON & JOHNSON VISION CARE, INC. (US) 2005-01-20 WO claimed
EP-1425052-A2 BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS Johnson & Johnson Vision Care, Inc. (US) 2004-06-09 EP claimed
EP-1425053-A2 BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS Johnson & Johnson Vision Care, Inc. (US) 2004-06-09 EP claimed
US-20040002556-A1 Macromer forming catalysts JOHNSON & JOHNSON VISION CARE, INC. 2004-01-01 US claimed
WO-2004000888-A1 MACROMER FORMING CATALYSTS JOHNSON & JOHNSON VISION CARE, INC. (US) 2003-12-31 WO claimed
US-20030162862-A1 Contact lenses for extended wear (without surface treatment, coating-free), formed by reacting polyvinylpyrrolidone and (2-methacryloxy-3-hydroxypropyloxy)propylbis(trimethylsiloxy) methylsilane, then curing JOHNSON & JOHNSON VISION CARE, INC. 2003-08-28 US claimed
US-20030125498-A1 Biomedical devices containing internal wetting agents JOHNSON & JOHNSON VISION CARE, INC. 2003-07-03 US claimed
WO-2003022322-A2 BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS JOHNSON & JOHNSON VISION CARE, INC. (US) 2003-03-20 WO claimed
WO-2003022321-A2 BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS JOHNSON & JOHNSON VISION CARE, INC. (US) 2003-03-20 WO claimed