Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 3/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.42 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4341894 | 0.83 | NOTUM (0.78) | NOTUMKDM4EALDH1A1MAPK1PDK2 | |
| SCHEMBL117343 | 0.81 | NOTUM (0.58) | NOTUMKDM4EALDH1A1MAPK1PDK2 | |
| SCHEMBL11286034 | 0.80 | NOTUM (0.64) | NOTUMALDH1A1PDK2KCNH2MAPT | |
| SCHEMBL30402678 | 0.80 | NOTUM (0.64) | NOTUMALDH1A1PDK2KCNH2MAPT | |
| SCHEMBL27777477 | 0.80 | KDM4E (0.57) | NOTUMKDM4EALDH1A1MAPK1PDK2 | |
| SCHEMBL27933790 | 0.80 | DGAT1 (0.44) | DGAT1UBE2NMAPT | |
| SCHEMBL173885 | 0.79 | NOTUM (0.67) | NOTUMKDM4EALDH1A1MAPK1PDK2 | |
| Hydrochloric Acid SCHEMBL7809916 | 0.78 | NOTUM (0.64) | NOTUMKDM4EALDH1A1MAPK1PDK2 | |
| SCHEMBL3831001 | 0.78 | NOTUM (0.50) | NOTUMKDM4EALDH1A1MAPK1PDK2 | |
| SCHEMBL4473412 | 0.77 | NOTUM (0.63) | NOTUMKDM4EALDH1A1MAPK1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106029640-B | Pyrazolinone compounds and application thereof | 泰普斯特医疗公司 | 2018-08-24 | — | — | CN | claimed |
| CN-1218472-A | Pharmaceutically useful compounds | ASTRA PHARMA PROD (GB) | 1999-06-02 | — | — | CN | claimed |
| CN-114450281-B | Inhibitor compounds | 辛塞拉治疗私人有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-116507607-A | Compounds and compositions as modulators of TLR signaling | 神经孔疗法股份有限公司 | 2023-07-28 | — | — | CN | disclosed |
| US-20220274970-A1 | INHIBITOR COMPOUNDS | Cincera Therapeutics Pty Ltd (AU) | 2022-09-01 | — | — | US | disclosed |
| CN-114450281-A | Inhibitor compounds | 辛塞拉治疗私人有限公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-113046772-B | Electrochemical synthesis method of 4-selenopyrazole derivative | 南华大学 | 2022-03-04 | — | — | CN | disclosed |
| WO-2021012018-A1 | INHIBITOR COMPOUNDS | Cincera Therapeutics Pty Ltd (AU) | 2021-01-28 | — | — | WO | disclosed |
| CN-105612153-B | Substituted heterocyclic sulfonamide compound as TRPA1 conditioning agents | 豪夫迈·罗氏有限公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-106029640-B | Pyrazolinone compounds and application thereof | 泰普斯特医疗公司 | 2018-08-24 | — | — | CN | disclosed |
| EP-2043970-B1 | IRON-COPPER CO-CATALYZED PROCESS FOR CARBON-CARBON OR CARBON-HETEROATOM BONDING | CENTRE NAT RECH SCIENT (FR) | 2018-04-18 | — | — | EP | disclosed |
| US-20080249150-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2008-10-09 | — | — | US | disclosed |
| US-7399778-B2 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH (US) | 2008-07-15 | — | — | US | disclosed |
| WO-2008004088-A2 | IRON-COPPER CO-CATALYZED PROCESS FOR CARBON-CARBON OR CARBON-HETEROATOM BONDING | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008004088-A2 | IRON-COPPER CO-CATALYZED PROCESS FOR CARBON-CARBON OR CARBON-HETEROATOM BONDING | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2008-01-10 | — | — | WO | disclosed |
| US-20070013295-A1 | Organic electroluminescent device | IDEMITSU KOSAN CO., LTD. (JP) | 2007-01-18 | — | — | US | disclosed |
| US-20070013295-A1 | Organic electroluminescent device | IDEMITSU KOSAN CO., LTD. (JP) | 2007-01-18 | — | — | US | disclosed |
| EP-1709003-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | Wyeth (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073198-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2005-08-11 | — | — | WO | disclosed |
| US-20050171180-A1 | Heterocyclic sulfonamide inhibtors of beta amyloid production containing an azole | WYETH (US) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220274970-A1 | INHIBITOR COMPOUNDS | SERPINB1, MMP1, SSB | NOTUM 2554/4885KDM4E 1551/4885ALDH1A1 1616/4885 |
| US-20080249150-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | APP, IAPP, PARK7 | NOTUM 1652/4885KDM4E 2422/4885ALDH1A1 4118/4885 |
| US-20050171180-A1 | Heterocyclic sulfonamide inhibtors of beta amyloid production containing an azole | IAPP, APP, CBR3 | NOTUM 2155/4885KDM4E 2756/4885ALDH1A1 3920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.