Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323624 | 0.88 | HSD11B1 (0.70) | HSD11B1NPC1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL3327946 | 0.82 | HSD11B1 (1.00) | HSD11B1POLBKMT2AHPGDALDH1A1 | |
| SCHEMBL3455073 | 0.80 | POLB (0.74) | HSD11B1NPC1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL13361608 | 0.79 | HSD11B1 (0.87) | HSD11B1POLBKMT2AHPGDALDH1A1 | |
| SCHEMBL3319514 | 0.78 | HSD11B1 (0.77) | HSD11B1NPC1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL13333114 | 0.74 | HSD11B1 (0.59) | HSD11B1POLBKMT2ASMN1; SMN2HPGD | |
| SCHEMBL13361636 | 0.73 | NPC1 (0.56) | HSD11B1NPC1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL3319986 | 0.71 | HPGD (0.58) | HSD11B1POLBKMT2AHPGDALDH1A1 | |
| SCHEMBL3321023 | 0.71 | HSD11B1 (0.74) | HSD11B1POLBKMT2AHPGDALDH1A1 | |
| SCHEMBL14142610 | 0.70 | LMNA (0.80) | HSD11B1NPC1POLBKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | HSD3B1, HSD3B2, HSD11B1 | HSD11B1 3/4885NPC1 1106/4885POLB 1708/4885 |
| US-20100120789-A1 | Compound | NR0B2, NR0B1, NR4A1 | HSD11B1 73/4885NPC1 2474/4885POLB 3372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.