Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6277566 | 0.81 | LMNA (0.45) | — | |
| SCHEMBL18553755 | 0.81 | HTR6 (0.62) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL29461939 | 0.81 | HTR6 (0.62) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4659557 | 0.80 | HTR6 (0.62) | HTR6ADRB1DRD2 | |
| SCHEMBL4573254 | 0.77 | HTR6 (1.00) | HTR6ADRB1CHRM2CHRM1 | |
| SCHEMBL9903630 | 0.77 | HTR6 (0.64) | HTR6ADRB1HTR1ADRD2HTR2A | |
| SCHEMBL3826873 | 0.77 | HTR6 (1.00) | HTR6ADRB1HTR1ADRD2HTR2A | |
| SCHEMBL4658341 | 0.76 | HTR6 (0.72) | HTR6HTR1AHTR7HTR2CHTR2B | |
| SCHEMBL3826762 | 0.75 | HTR6 (0.76) | HTR6ADRB1HTR1ADRD2HTR2A | |
| SCHEMBL3796417 | 0.75 | HTR6 (1.00) | HTR6HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120747-A1 | COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-05-13 | — | — | US | claimed |
| EP-1608635-B1 | PHENYL SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2009-09-16 | — | — | EP | claimed |
| CN-101500611-A | Combination of a cholinesterase inhibitor and a compound with 5-HT6 receptor affinity | ESTEVE LABOR DR (ES) | 2009-08-05 | — | — | CN | claimed |
| EP-2040755-A1 | COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-04-01 | — | — | EP | claimed |
| US-20090012099-A1 | Novel Compounds | GLAXO GROUP LIMITED | 2009-01-08 | — | — | US | claimed |
| US-7439245-B2 | e.g. 1-(3-Phenylsulfonyl-phenyl)piperazine; serotonin receptor modulator; anxiolytic agent, antidepressant, cognition activator; schizophrenia, obesity, Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2008-10-21 | — | — | US | claimed |
| US-20080214571-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED | 2008-09-04 | — | — | US | claimed |
| WO-2007147883-A1 | COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-12-27 | — | — | WO | claimed |
| US-7262188-B2 | Phenyl sulfone derivatives and their use in the treatment of CNS disorders | GLAXO GROUP LIMITED (GB) | 2007-08-28 | — | — | US | claimed |
| US-20060281757-A1 | Phenyl sulfone derivatives and their use in the treatment of cns disorders | GLAXO GROUP LIMITED (GB) | 2006-12-14 | — | — | US | claimed |
| EP-1608635-A1 | PHENYL SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-12-28 | — | — | EP | claimed |
| WO-2004080986-A1 | PHENYL SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-09-23 | — | — | WO | claimed |
| US-20100120747-A1 | COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-05-13 | — | — | US | disclosed |
| US-20100120747-A1 | COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-05-13 | — | — | US | disclosed |
| US-20100120747-A1 | COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-05-13 | — | — | US | disclosed |
| EP-1608635-B1 | PHENYL SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2009-09-16 | — | — | EP | disclosed |
| US-7262188-B2 | Phenyl sulfone derivatives and their use in the treatment of CNS disorders | GLAXO GROUP LIMITED (GB) | 2007-08-28 | — | — | US | disclosed |
| US-20060281757-A1 | Phenyl sulfone derivatives and their use in the treatment of cns disorders | GLAXO GROUP LIMITED (GB) | 2006-12-14 | — | — | US | disclosed |
| EP-1608635-A1 | PHENYL SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004080986-A1 | PHENYL SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012099-A1 | Novel Compounds | PSEN2, PSEN1, BACE1 | HTR6 269/4885ADRB1 1870/4885HTR1A 717/4885 |
| US-20080214571-A1 | NOVEL COMPOUNDS | NPSR1, GABRE, HTR2B | HTR6 4/4885ADRB1 171/4885HTR1A 9/4885 |
| US-20100120747-A1 | COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | HTR6, AANAT, ACHE | HTR6 1/4885ADRB1 213/4885HTR1A 11/4885 |
| US-20060281757-A1 | Phenyl sulfone derivatives and their use in the treatment of cns disorders | PMP22, SNCA, SLC6A3 | HTR6 105/4885ADRB1 1152/4885HTR1A 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.