Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12313812 | 0.82 | RIPK1 (0.63) | RIPK1TRPM8HSD11B1CYP3A4RAB9A | |
| SCHEMBL3323893 | 0.81 | RIPK1 (0.75) | RIPK1TRPM8HSD11B1CYP3A4RAB9A | |
| SCHEMBL21400322 | 0.78 | RIPK1 (0.62) | RIPK1TRPM8HSD11B1CYP3A4RAB9A | |
| SCHEMBL14073887 | 0.78 | TRPM8 (0.56) | RIPK1TRPM8HSD11B1CYP3A4RAB9A | |
| SCHEMBL9668325 | 0.78 | RIPK1 (0.57) | RIPK1TRPM8HSD11B1CYP3A4RAB9A | |
| SCHEMBL6121860 | 0.77 | RIPK1 (0.61) | RIPK1TRPM8HSD11B1CYP3A4RAB9A | |
| SCHEMBL17882261 | 0.77 | RIPK1 (1.00) | RIPK1TRPM8HSD11B1CYP3A4CYP2D6 | |
| SCHEMBL6122487 | 0.77 | RIPK1 (0.60) | RIPK1TRPM8HSD11B1CYP3A4RAB9A | |
| SCHEMBL3325606 | 0.75 | RIPK1 (0.66) | RIPK1TRPM8HSD11B1CYP3A4RAB9A | |
| SCHEMBL13870657 | 0.74 | RIPK1 (0.57) | RIPK1TRPM8HSD11B1CYP3A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | HSD3B1, HSD3B2, HSD11B1 | RIPK1 3901/4885TRPM8 4621/4885HSD11B1 3/4885 |
| US-20100120789-A1 | Compound | NR0B2, NR0B1, NR4A1 | RIPK1 2438/4885TRPM8 2044/4885HSD11B1 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.