Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.72 |
| ▸ | HTR1A | P08908 | 7/20 | 0.57 |
| ▸ | HTR1D | P28221 | 7/20 | 0.57 |
| ▸ | HTR1B | P28222 | 7/20 | 0.57 |
| ▸ | HTR7 | P34969 | 4/20 | 0.57 |
| ▸ | HTR2C | P28335 | 4/20 | 0.57 |
| ▸ | HTR2A | P28223 | 3/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | HTR1E | P28566 | 1/20 | 0.57 |
| ▸ | HTR1F | P30939 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3152787 | 0.84 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| Hydrochloric Acid SCHEMBL3147766 | 0.83 | HTR6 (0.98) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL7195128 | 0.79 | HTR6 (0.72) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL1460571 | 0.78 | NPSR1 (0.60) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL3147165 | 0.77 | HTR6 (0.77) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL3147519 | 0.76 | HTR6 (0.60) | HTR6 | |
| SCHEMBL3874098 | 0.75 | HTR6 (0.60) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL6981823 | 0.74 | HTR6 (0.80) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL6972216 | 0.74 | HTR6 (0.80) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL10239970 | 0.74 | HTR6 (0.63) | HTR6HTR1AHTR1DHTR1BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120747-A1 | COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-05-13 | — | — | US | disclosed |
| US-20090005417-A1 | Substituted Indazolyl Sulfonamide and 2,3-Dihydro-Indolyl Sulfonamide Compounds, their Preparation and Use in Medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-01-01 | — | — | US | disclosed |
| US-20090005417-A1 | Substituted Indazolyl Sulfonamide and 2,3-Dihydro-Indolyl Sulfonamide Compounds, their Preparation and Use in Medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120747-A1 | COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | HTR6, AANAT, ACHE | HTR6 1/4885HTR1A 11/4885HTR1D 27/4885 |
| US-20090005417-A1 | Substituted Indazolyl Sulfonamide and 2,3-Dihydro-Indolyl Sulfonamide Compounds, their Preparation and Use in Medicaments | HTR6, TPH2, HTR5A | HTR6 1/4885HTR1A 11/4885HTR1D 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.