Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | FABP7 | O15540 | 2/20 | 0.43 |
| ▸ | FABP3 | P05413 | 2/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606839 | 0.96 | KCNQ3 (0.50) | KCNQ3KCNQ2SLC6A2SLC6A4HPGD | |
| SCHEMBL25355746 | 0.89 | SLC9A1 (0.54) | SLC6A2HPGDSLC9A1ALDH1A1HRH3 | |
| SCHEMBL4606553 | 0.86 | SLC6A2 (0.61) | KCNQ3KCNQ2SLC6A2SLC6A4SLC9A1 | |
| SCHEMBL22492058 | 0.85 | KCNQ3 (0.56) | KCNQ3KCNQ2SLC6A2SLC6A4HPGD | |
| SCHEMBL838634 | 0.85 | KCNQ3 (0.56) | KCNQ3KCNQ2SLC6A2SLC6A4HPGD | |
| SCHEMBL22492062 | 0.85 | KCNQ3 (0.56) | KCNQ3KCNQ2SLC6A2SLC6A4HPGD | |
| SCHEMBL12354198 | 0.85 | KCNQ3 (0.56) | KCNQ3KCNQ2SLC6A2SLC6A4HPGD | |
| SCHEMBL28946655 | 0.84 | HPGD (0.49) | SLC6A2SLC6A4HPGDSLC9A1ALDH1A1 | |
| SCHEMBL12592461 | 0.83 | SLC6A2 (0.56) | KCNQ3KCNQ2SLC6A2SLC6A4HPGD | |
| SCHEMBL1752024 | 0.83 | SLC6A2 (0.56) | KCNQ3KCNQ2SLC6A2SLC6A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346848-B1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | disclosed |
| US-8318749-B2 | Quinazoline derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20100125078-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125078-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | SLC6A3, OPRK1, HTR3A | KCNQ3 40/4885KCNQ2 201/4885SLC6A2 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.