Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770121 | 0.84 | ALDH1A1 (0.43) | KMT2AHSD11B1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1770044 | 0.83 | CYP19A1 (0.53) | KMT2AHSD11B1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL3321390 | 0.83 | MEN1 (0.47) | KMT2AHSD11B1HPGDALDH1A1NPSR1 | |
| SCHEMBL3319547 | 0.82 | P2RX7 (0.46) | KMT2AHSD11B1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3323351 | 0.80 | NPC1 (0.51) | KMT2ADRD2DRD4HSD11B1HPGD | |
| SCHEMBL3327784 | 0.78 | ALDH1A1 (0.47) | KMT2AHSD11B1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1769963 | 0.77 | HSD11B1 (0.62) | KMT2AHSD11B1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12596448 | 0.76 | ALDH1A1 (0.44) | KMT2AHSD11B1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1770249 | 0.75 | ALDH1A1 (0.40) | HSD11B1HPGDALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL5327570 | 0.75 | P2RX7 (0.46) | KMT2AHSD11B1HPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
| EP-1861384-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Sterix Limited (GB) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006100502-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | STERIX LIMITED (GB) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | HSD3B1, HSD3B2, HSD11B1 | KMT2A 3083/4885DRD2 367/4885DRD4 365/4885 |
| US-20100120789-A1 | Compound | NR0B2, NR0B1, NR4A1 | KMT2A 2533/4885DRD2 175/4885DRD4 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.